7a5u

X-ray diffraction
1.5Å resolution

Structure of E37A BlaC from Mycobacterium tuberculosis

Released:

Function and Biology Details

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-lactamase Chain: A
Molecule details ›
Chain: A
Length: 274 amino acids
Theoretical weight: 29.47 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WKD3 (Residues: 43-307; Coverage: 97%)
Gene names: MTCY49.07c, Rv2068c, blaA, blaC
Sequence domains: Beta-lactamase enzyme family

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P21
Unit cell:
a: 38.56Å b: 54.739Å c: 54.509Å
α: 90° β: 95° γ: 90°
R-values:
R R work R free
0.127 0.125 0.176
Expression system: Escherichia coli BL21(DE3)