› 7a5s

Electron Microscopy
3.9Å resolution

Complex of SARS-CoV-2 spike and CR3022 Fab (Homogeneous Refinement)

Released:
DOI: 10.2210/pdb7a5s/pdb
PDB 7a5s coloured by chain and viewed from the front.
PDB 7a5s coloured by chain and viewed from the side.
PDB 7a5s coloured by chain and viewed from the top.
Source organisms:
Primary publication:
Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein.
Wrobel AG, Benton DJ, Hussain S, Harvey R, Martin SR, Roustan C, Rosenthal PB, Skehel JJ, Gamblin SJ
Nat Commun 11 5337 (2020)
PMID: 33087721
Related structures: EMD-11647

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
CR3022 Fab Heavy Chain Chains: H, I
Molecule details ›
Chains: H, I
Length: 256 amino acids
Theoretical weight: 27.41 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
CR3022 Fab Light Chain Chains: L, M
Molecule details ›
Chains: L, M
Length: 240 amino acids
Theoretical weight: 26.51 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Spike glycoprotein Chains: A, B
Molecule details ›
Chains: A, B
Length: 1287 amino acids
Theoretical weight: 142.41 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-11647
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Structural Analysis of Neutralizing Epitopes of the SARS-CoV-2 Spike to Guide Therapy and Vaccine Design Strategies.
Finkelstein et al. (2021)