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Structure of the split human mitoribosomal large subunit with P-and E-site mt-tRNAs

Electron Microscopy
3.1Å resolution
PDB entry 7a5j coloured by chain, front view.
PDB entry 7a5j coloured by chain, side view.
PDB entry 7a5j coloured by chain, top view.
Source organisms:
Assembly composition:
hetero 63-mer (preferred)
Entry contents: 58 distinct polypeptide molecules
3 distinct RNA molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero 63-mer
Accessible surface area: 550918.84 Å2
Buried surface area: 351356.73 Å2
Dissociation area: 2,521.9 Å2
Dissociation energy (ΔGdiss): -22.72 kcal/mol
Dissociation entropy (TΔSdiss): 46.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-216207

Macromolecules

Large ribosomal subunit protein uL2m
Chain: D
Length: 305 amino acids
Theoretical weight: 33.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q5T653 (Residues: 1-305; Coverage: 100%)
Gene names: CGI-22, MRPL2
Pfam:
InterPro:
Large ribosomal subunit protein uL2m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein uL2m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein uL2m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein uL3m
Chain: E
Length: 348 amino acids
Theoretical weight: 38.69 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P09001 (Residues: 1-348; Coverage: 100%)
Gene names: MRL3, MRPL3, RPML3
Pfam: Ribosomal protein L3
InterPro:
Large ribosomal subunit protein uL3m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein uL3m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein uL3m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein uL4m
Chain: F
Length: 311 amino acids
Theoretical weight: 34.97 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYD3 (Residues: 1-311; Coverage: 100%)
Gene names: CDABP0091, CGI-28, MRPL4
Pfam: Ribosomal protein L4/L1 family
InterPro:
Large ribosomal subunit protein uL4m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein uL4m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein uL4m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein bL9m
Chains: C, H
Length: 267 amino acids
Theoretical weight: 30.3 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYD2 (Residues: 1-267; Coverage: 100%)
Gene name: MRPL9
Pfam: Ribosomal protein L9, N-terminal domain
InterPro:
Large ribosomal subunit protein bL9m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein bL9m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein bL9m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein uL10m
Chain: I
Length: 261 amino acids
Theoretical weight: 29.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q7Z7H8 (Residues: 1-261; Coverage: 100%)
Gene names: MRPL10, MRPL8, RPML8
Pfam: Ribosomal protein L10
InterPro:
Large ribosomal subunit protein uL10m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein uL10m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein uL10m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein uL11m
Chain: J
Length: 192 amino acids
Theoretical weight: 20.72 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y3B7 (Residues: 1-192; Coverage: 100%)
Gene names: CGI-113, MRPL11
Pfam:
InterPro:
Large ribosomal subunit protein uL11m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein uL11m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein uL11m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein uL13m
Chain: K
Length: 178 amino acids
Theoretical weight: 20.72 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYD1 (Residues: 1-178; Coverage: 100%)
Gene name: MRPL13
Pfam: Ribosomal protein L13
InterPro:
Large ribosomal subunit protein uL13m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein uL13m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein uL13m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein uL14m
Chain: L
Length: 145 amino acids
Theoretical weight: 15.97 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q6P1L8 (Residues: 1-145; Coverage: 100%)
Gene names: MRPL14, MRPL32, RPML32
Pfam: Ribosomal protein L14p/L23e
InterPro:
Large ribosomal subunit protein uL14m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein uL14m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein uL14m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein uL15m
Chain: M
Length: 296 amino acids
Theoretical weight: 33.47 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9P015 (Residues: 1-296; Coverage: 100%)
Gene names: HSPC145, MRPL15
Pfam: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
InterPro:
Large ribosomal subunit protein uL15m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein uL15m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein uL15m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein uL16m
Chain: N
Length: 251 amino acids
Theoretical weight: 28.5 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NX20 (Residues: 1-251; Coverage: 100%)
Gene names: MRPL16, PNAS-111
Pfam: Ribosomal protein L16p/L10e
InterPro:
Large ribosomal subunit protein uL16m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein uL16m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein uL16m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein bL17m
Chain: O
Length: 175 amino acids
Theoretical weight: 20.08 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NRX2 (Residues: 1-175; Coverage: 100%)
Gene names: LIP2, MRPL17
Pfam: Ribosomal protein L17
InterPro:
Large ribosomal subunit protein bL17m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein bL17m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein bL17m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein uL18m
Chain: P
Length: 179 amino acids
Theoretical weight: 20.47 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9H0U6 (Residues: 1-180; Coverage: 99%)
Gene names: HSPC071, MRPL18
Pfam: Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast
InterPro:
Large ribosomal subunit protein uL18m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein uL18m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein uL18m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein bL19m
Chain: Q
Length: 292 amino acids
Theoretical weight: 33.58 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P49406 (Residues: 1-292; Coverage: 100%)
Gene names: KIAA0104, MRPL15, MRPL19
Pfam: Ribosomal protein L19
InterPro:
Large ribosomal subunit protein bL19m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein bL19m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein bL19m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein bL20m
Chain: R
Length: 149 amino acids
Theoretical weight: 17.48 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYC9 (Residues: 1-149; Coverage: 100%)
Gene name: MRPL20
Pfam: Ribosomal protein L20
InterPro:
Large ribosomal subunit protein bL20m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein bL20m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein bL20m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein bL21m
Chain: S
Length: 205 amino acids
Theoretical weight: 22.85 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q7Z2W9 (Residues: 1-205; Coverage: 100%)
Gene name: MRPL21
Pfam: Ribosomal prokaryotic L21 protein
InterPro:
Large ribosomal subunit protein bL21m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein bL21m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein bL21m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein uL22m
Chain: T
Length: 212 amino acids
Theoretical weight: 24.37 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: E7ESL0 (Residues: 1-212; Coverage: 100%)
Gene name: MRPL22
Pfam: Ribosomal protein L22p/L17e
InterPro:
Large ribosomal subunit protein uL22m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein uL22m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein uL22m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein uL23m
Chain: U
Length: 153 amino acids
Theoretical weight: 17.81 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q16540 (Residues: 1-153; Coverage: 100%)
Gene names: L23MRP, MRPL23, RPL23L
Pfam: Ribosomal protein L23
InterPro:
Large ribosomal subunit protein uL23m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein uL23m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein uL23m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein uL24m
Chain: V
Length: 216 amino acids
Theoretical weight: 24.95 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96A35 (Residues: 1-216; Coverage: 100%)
Gene name: MRPL24
Pfam:
InterPro:
Large ribosomal subunit protein uL24m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein uL24m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein uL24m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein bL27m
Chain: W
Length: 148 amino acids
Theoretical weight: 16.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9P0M9 (Residues: 1-148; Coverage: 100%)
Gene names: HSPC250, MRPL27
Pfam: Ribosomal L27 protein
InterPro: Large ribosomal subunit protein bL27
Large ribosomal subunit protein bL27m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein bL27m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein bL27m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein bL28m
Chain: X
Length: 256 amino acids
Theoretical weight: 30.2 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13084 (Residues: 1-256; Coverage: 100%)
Gene names: MAAT1, MRPL28
Pfam: Ribosomal L28 family
InterPro:
Large ribosomal subunit protein bL28m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein bL28m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein bL28m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein uL29m
Chain: Y
Length: 250 amino acids
Theoretical weight: 29.51 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9HD33 (Residues: 1-250; Coverage: 100%)
Gene names: CGI-204, MRPL47, NCM1
Pfam: Mitochondrial 39-S ribosomal protein L47 (MRP-L47)
InterPro:
Large ribosomal subunit protein uL29m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein uL29m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein uL29m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein uL30m
Chain: Z
Length: 161 amino acids
Theoretical weight: 18.58 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8TCC3 (Residues: 1-161; Coverage: 100%)
Gene names: HSPC249, MRPL28, MRPL30, RPML28
Pfam: Ribosomal protein L30p/L7e
InterPro:
Large ribosomal subunit protein uL30m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein uL30m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein uL30m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein bL32m
Chain: 0
Length: 188 amino acids
Theoretical weight: 21.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYC8 (Residues: 1-188; Coverage: 100%)
Gene names: HSPC283, MRPL32
Pfam: Ribosomal L32p protein family
InterPro:
Large ribosomal subunit protein bL32m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein bL32m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein bL32m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein bL33m
Chain: 1
Length: 65 amino acids
Theoretical weight: 7.64 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75394 (Residues: 1-65; Coverage: 100%)
Gene names: C2orf1, MRPL33
Pfam: Ribosomal protein L33
InterPro:
Large ribosomal subunit protein bL33m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein bL33m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein bL33m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein bL34m
Chain: 2
Length: 92 amino acids
Theoretical weight: 10.18 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BQ48 (Residues: 1-92; Coverage: 100%)
Gene name: MRPL34
Pfam: Ribosomal protein L34
InterPro: Large ribosomal subunit protein bL34
Large ribosomal subunit protein bL34m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein bL34m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein bL34m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein bL35m
Chain: 3
Length: 188 amino acids
Theoretical weight: 21.56 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NZE8 (Residues: 1-188; Coverage: 100%)
Gene names: BM-007, MRPL35
Pfam: Ribosomal protein L35
InterPro:
Large ribosomal subunit protein bL35m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein bL35m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein bL35m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein bL36m
Chain: 4
Length: 103 amino acids
Theoretical weight: 11.81 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9P0J6 (Residues: 1-103; Coverage: 100%)
Gene names: BRIP1, MRPL36
Pfam: Ribosomal protein L36
InterPro:
Large ribosomal subunit protein bL36m in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein bL36m in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein bL36m in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL37
Chain: 5
Length: 423 amino acids
Theoretical weight: 48.18 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BZE1 (Residues: 1-423; Coverage: 100%)
Gene names: HSPC235, MRPL2, MRPL37, RPML2
Pfam: Mitochondrial 28S ribosomal protein S30 (PDCD9)
InterPro: Large ribosomal subunit protein mL37/mL65
Large ribosomal subunit protein mL37 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL37 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL37 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL38
Chain: 6
Length: 380 amino acids
Theoretical weight: 44.66 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96DV4 (Residues: 1-380; Coverage: 100%)
Gene names: HSPC262, MRPL38
Pfam: Phosphatidylethanolamine-binding protein
InterPro:
Large ribosomal subunit protein mL38 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL38 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL38 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL39
Chain: 7
Length: 338 amino acids
Theoretical weight: 38.76 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NYK5 (Residues: 1-338; Coverage: 100%)
Gene names: C21orf92, MRPL39, MRPL5, MSTP003, PRED22, RPML5
InterPro:
Large ribosomal subunit protein mL39 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL39 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL39 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL40
Chain: 8
Length: 206 amino acids
Theoretical weight: 24.53 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NQ50 (Residues: 1-206; Coverage: 100%)
Gene names: MRPL40, NLVCF, URIM
Pfam: Mitochondrial ribosomal protein L28
InterPro:
Large ribosomal subunit protein mL40 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL40 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL40 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL41
Chain: 9
Length: 137 amino acids
Theoretical weight: 15.4 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8IXM3 (Residues: 1-137; Coverage: 100%)
Gene names: BMRP, MRPL27, MRPL41, PIG3, RPML27
Pfam: Mitochondrial ribosomal protein L27
InterPro: Large ribosomal subunit protein mL41
Large ribosomal subunit protein mL41 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL41 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL41 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL42
Chain: a
Length: 142 amino acids
Theoretical weight: 16.69 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y6G3 (Residues: 1-142; Coverage: 100%)
Gene names: HSPC204, MRPL31, MRPL42, MRPS32, PTD007, RPML31
Pfam: Mitochondrial 28S ribosomal protein S32
InterPro: Large ribosomal subunit protein mL42
Large ribosomal subunit protein mL42 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL42 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL42 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL43
Chain: b
Length: 155 amino acids
Theoretical weight: 17.45 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8N983 (Residues: 1-155; Coverage: 72%)
Gene name: MRPL43
Pfam: Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
InterPro:
Large ribosomal subunit protein mL43 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL43 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL43 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL44
Chain: c
Length: 332 amino acids
Theoretical weight: 37.58 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9H9J2 (Residues: 1-332; Coverage: 100%)
Gene name: MRPL44
InterPro:
Large ribosomal subunit protein mL44 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL44 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL44 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL45
Chain: d
Length: 306 amino acids
Theoretical weight: 35.4 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BRJ2 (Residues: 1-306; Coverage: 100%)
Gene name: MRPL45
Pfam: Tim44-like domain
InterPro:
Large ribosomal subunit protein mL45 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL45 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL45 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL46
Chain: e
Length: 279 amino acids
Theoretical weight: 31.75 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9H2W6 (Residues: 1-279; Coverage: 100%)
Gene names: C15orf4, LIECG2, MRPL46
Pfam: 39S mitochondrial ribosomal protein L46
InterPro:
Large ribosomal subunit protein mL46 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL46 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL46 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL48
Chain: f
Length: 194 amino acids
Theoretical weight: 21.86 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96GC5 (Residues: 1-194; Coverage: 92%)
Gene names: CGI-118, HSPC290, MRPL48
Pfam: Ribosomal protein S10p/S20e
InterPro:
Large ribosomal subunit protein mL48 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL48 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL48 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL49
Chain: g
Length: 166 amino acids
Theoretical weight: 19.23 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13405 (Residues: 1-166; Coverage: 100%)
Gene names: C11orf4, MRPL49, NOF1, OK/SW-cl.67
Pfam: Mitochondrial large subunit ribosomal protein (Img2)
InterPro: Large ribosomal subunit protein mL49
Large ribosomal subunit protein mL49 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL49 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL49 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL50
Chain: h
Length: 158 amino acids
Theoretical weight: 18.35 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8N5N7 (Residues: 1-158; Coverage: 100%)
Gene name: MRPL50
Pfam: Ribosomal subunit 39S
InterPro: Large ribosomal subunit protein mL50
Large ribosomal subunit protein mL50 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL50 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL50 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL51
Chain: i
Length: 128 amino acids
Theoretical weight: 15.13 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q4U2R6 (Residues: 1-128; Coverage: 100%)
Gene names: CDA09, HSPC241, MRP64, MRPL51
Pfam: Mitochondrial ribosomal subunit
InterPro: Large ribosomal subunit protein mL51
Large ribosomal subunit protein mL51 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL51 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL51 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL52
Chain: j
Length: 123 amino acids
Theoretical weight: 13.7 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q86TS9 (Residues: 1-123; Coverage: 100%)
Gene name: MRPL52
Pfam: Mitoribosomal protein mL52
InterPro: Large ribosomal subunit protein mL52
Large ribosomal subunit protein mL52 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL52 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL52 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL53
Chain: k
Length: 112 amino acids
Theoretical weight: 12.13 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96EL3 (Residues: 1-112; Coverage: 100%)
Gene name: MRPL53
Pfam: 39S ribosomal protein L53/MRP-L53
InterPro: Large ribosomal subunit protein mL53
Large ribosomal subunit protein mL53 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL53 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL53 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL54
Chain: l
Length: 138 amino acids
Theoretical weight: 15.84 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q6P161 (Residues: 1-138; Coverage: 100%)
Gene name: MRPL54
Pfam: Mitochondrial ribosomal protein L37
InterPro: Large ribosomal subunit protein mL54
Large ribosomal subunit protein mL54 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL54 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL54 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL55
Chain: m
Length: 128 amino acids
Theoretical weight: 15.16 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q7Z7F7 (Residues: 1-128; Coverage: 100%)
Gene names: MRPL55, UNQ5835/PRO19675
Pfam: Mitochondrial ribosomal protein L55
InterPro:
Large ribosomal subunit protein mL55 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL55 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL55 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL63
Chain: o
Length: 102 amino acids
Theoretical weight: 12.29 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BQC6 (Residues: 1-102; Coverage: 100%)
Gene names: MRP63, MRPL57
Pfam: Mitochondrial ribosome protein 63
InterPro: Large ribosomal subunit protein mL63
Large ribosomal subunit protein mL63 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL63 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL63 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL62
Chain: p
Length: 206 amino acids
Theoretical weight: 23.67 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q14197 (Residues: 1-206; Coverage: 100%)
Gene names: DS1, ICT1, MRPL58
Pfam: RF-1 domain
InterPro: Peptide chain release factor class I
Large ribosomal subunit protein mL62 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL62 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL62 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL64
Chain: q
Length: 222 amino acids
Theoretical weight: 25.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8TAE8 (Residues: 1-222; Coverage: 100%)
Gene names: GADD45GIP1, MRPL59, PLINP1, PRG6
Pfam: Growth arrest and DNA-damage-inducible proteins-interacting protein 1
InterPro:
Large ribosomal subunit protein mL64 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL64 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL64 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL66
Chain: r
Length: 196 amino acids
Theoretical weight: 22.22 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NVS2 (Residues: 1-196; Coverage: 100%)
Gene name: MRPS18A
Pfam: Ribosomal protein S18
InterPro:
Large ribosomal subunit protein mL66 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL66 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL66 in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein mL65
Chain: s
Length: 439 amino acids
Theoretical weight: 50.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NP92 (Residues: 1-439; Coverage: 100%)
Gene names: BM-047, MRPS30, PDCD9
Pfam: Mitochondrial 28S ribosomal protein S30 (PDCD9)
InterPro:
Large ribosomal subunit protein mL65 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein mL65 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein mL65 in PDB entry 7a5j, assembly 1, top view.
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Unknown protein/protein extension
Chain: t
Length: 28 amino acids
Theoretical weight: 2.4 KDa
Source organism: Homo sapiens
Unknown protein/protein extension in PDB entry 7a5j, assembly 1, front view.
Unknown protein/protein extension in PDB entry 7a5j, assembly 1, side view.
Unknown protein/protein extension in PDB entry 7a5j, assembly 1, top view.
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Mitochondrial assembly of ribosomal large subunit protein 1
Chain: u
Length: 234 amino acids
Theoretical weight: 26.2 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96EH3 (Residues: 1-234; Coverage: 100%)
Gene names: C7orf30, MALSU1
Pfam: Ribosomal silencing factor during starvation
InterPro:
Mitochondrial assembly of ribosomal large subunit protein 1 in PDB entry 7a5j, assembly 1, front view.
Mitochondrial assembly of ribosomal large subunit protein 1 in PDB entry 7a5j, assembly 1, side view.
Mitochondrial assembly of ribosomal large subunit protein 1 in PDB entry 7a5j, assembly 1, top view.
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Mitochondrial ribosome and complex I assembly factor AltMIEF1
Chain: v
Length: 70 amino acids
Theoretical weight: 8.46 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: L0R8F8 (Residues: 1-70; Coverage: 100%)
Gene names: AltMIEF1, AltMiD51, MIEF1
Pfam: Complex 1 protein (LYR family)
InterPro:
Mitochondrial ribosome and complex I assembly factor AltMIEF1 in PDB entry 7a5j, assembly 1, front view.
Mitochondrial ribosome and complex I assembly factor AltMIEF1 in PDB entry 7a5j, assembly 1, side view.
Mitochondrial ribosome and complex I assembly factor AltMIEF1 in PDB entry 7a5j, assembly 1, top view.
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Acyl carrier protein, mitochondrial
Chain: w
Length: 156 amino acids
Theoretical weight: 17.77 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O14561 (Residues: 1-156; Coverage: 100%)
Gene name: NDUFAB1
Pfam: Phosphopantetheine attachment site
InterPro:
Acyl carrier protein, mitochondrial in PDB entry 7a5j, assembly 1, front view.
Acyl carrier protein, mitochondrial in PDB entry 7a5j, assembly 1, side view.
Acyl carrier protein, mitochondrial in PDB entry 7a5j, assembly 1, top view.
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Large ribosomal subunit protein uL1
Chain: n
Length: 229 amino acids
Theoretical weight: 24.87 KDa
Source organism: Thermus thermophilus HB27
UniProt:
  • Canonical: P27150 (Residues: 1-229; Coverage: 100%)
Gene names: rpl1, rplA
Pfam: Ribosomal protein L1p/L10e family
InterPro:
Large ribosomal subunit protein uL1 in PDB entry 7a5j, assembly 1, front view.
Large ribosomal subunit protein uL1 in PDB entry 7a5j, assembly 1, side view.
Large ribosomal subunit protein uL1 in PDB entry 7a5j, assembly 1, top view.
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nascent chain
Chain: Y2
Length: 29 amino acids
Theoretical weight: 2.49 KDa
Source organism: Homo sapiens
nascent chain in PDB entry 7a5j, assembly 1, front view.
nascent chain in PDB entry 7a5j, assembly 1, side view.
nascent chain in PDB entry 7a5j, assembly 1, top view.
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Unknown protein/protein extension
Chain: y
Length: 32 amino acids
Theoretical weight: 2.74 KDa
Source organism: Homo sapiens
Unknown protein/protein extension in PDB entry 7a5j, assembly 1, front view.
Unknown protein/protein extension in PDB entry 7a5j, assembly 1, side view.
Unknown protein/protein extension in PDB entry 7a5j, assembly 1, top view.
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unknown protein/protein extension
Chain: z
Length: 14 amino acids
Theoretical weight: 1.21 KDa
Source organism: Homo sapiens
unknown protein/protein extension in PDB entry 7a5j, assembly 1, front view.
unknown protein/protein extension in PDB entry 7a5j, assembly 1, side view.
unknown protein/protein extension in PDB entry 7a5j, assembly 1, top view.
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RNA chain A
Name: 16S ribosomal RNA
Representative chains: A
Length: 1559 nucleotides
Theoretical weight: 500.02 KDa
Rfam: Bacterial large subunit ribosomal RNA
16S ribosomal RNA in PDB entry 7a5j, assembly 1, front view.
16S ribosomal RNA in PDB entry 7a5j, assembly 1, side view.
16S ribosomal RNA in PDB entry 7a5j, assembly 1, top view.
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RNA chain B
Name: mt-tRNAVal
Representative chains: B
Length: 69 nucleotides
Theoretical weight: 22.02 KDa
mt-tRNAVal in PDB entry 7a5j, assembly 1, front view.
mt-tRNAVal in PDB entry 7a5j, assembly 1, side view.
mt-tRNAVal in PDB entry 7a5j, assembly 1, top view.
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RNA chains G, x
Name: mt-tRNA
Representative chains: G, x
Length: 73 nucleotides
Theoretical weight: 23.38 KDa
Rfam: tRNA
mt-tRNA in PDB entry 7a5j, assembly 1, front view.
mt-tRNA in PDB entry 7a5j, assembly 1, side view.
mt-tRNA in PDB entry 7a5j, assembly 1, top view.
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