› 7a5g

Electron Microscopy
4.33Å resolution

Structure of the elongating human mitoribosome bound to mtEF-Tu.GMPPCP and A/T mt-tRNA

Released:
DOI: 10.2210/pdb7a5g/pdb
PDB entry 7a5g coloured by chain, front view.
PDB entry 7a5g coloured by chain, side view.
PDB entry 7a5g coloured by chain, top view.
Source organisms:
Primary publication:
Elongational stalling activates mitoribosome-associated quality control.
Desai N, Yang H, Chandrasekaran V, Kazi R, Minczuk M, Ramakrishnan V
Science 370 1105-1110 (2020)
PMID: 33243891
Related structures: EMD-11642

Function and Biology Details

Reaction catalysed: 
N-substituted aminoacyl-tRNA + H(2)O = N-substituted amino acid + tRNA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 94-mer (preferred)
PDBe Complex ID:
PDB-CPX-292972 (preferred)
Entry contents:
84 distinct polypeptide molecules
7 distinct RNA molecules
Macromolecules (91 distinct):
nascent chain Chain: Y2
Molecule details ›
Chain: Y2
Length: 29 amino acids
Theoretical weight: 2.08 KDa
Source organism: Homo sapiens
Large ribosomal subunit protein uL2m Chain: D3
Molecule details ›
Chain: D3
Length: 305 amino acids
Theoretical weight: 33.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q5T653 (Residues: 1-305; Coverage: 100%)
Gene names: CGI-22, MRPL2
Sequence domains:
Large ribosomal subunit protein uL3m Chain: E3
Molecule details ›
Chain: E3
Length: 348 amino acids
Theoretical weight: 38.69 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P09001 (Residues: 1-348; Coverage: 100%)
Gene names: MRL3, MRPL3, RPML3
Sequence domains: Ribosomal protein L3
Large ribosomal subunit protein uL4m Chain: F3
Molecule details ›
Chain: F3
Length: 311 amino acids
Theoretical weight: 34.97 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYD3 (Residues: 1-311; Coverage: 100%)
Gene names: CDABP0091, CGI-28, MRPL4
Sequence domains: Ribosomal protein L4/L1 family
Large ribosomal subunit protein bL9m Chains: D, H3
Molecule details ›
Chains: D, H3
Length: 267 amino acids
Theoretical weight: 30.3 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYD2 (Residues: 1-267; Coverage: 100%)
Gene name: MRPL9
Sequence domains:
Large ribosomal subunit protein uL10m Chain: I3
Molecule details ›
Chain: I3
Length: 261 amino acids
Theoretical weight: 29.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q7Z7H8 (Residues: 1-261; Coverage: 100%)
Gene names: MRPL10, MRPL8, RPML8
Sequence domains: Ribosomal protein L10
Large ribosomal subunit protein uL11m Chain: J3
Molecule details ›
Chain: J3
Length: 192 amino acids
Theoretical weight: 20.72 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y3B7 (Residues: 1-192; Coverage: 100%)
Gene names: CGI-113, MRPL11
Sequence domains:
Large ribosomal subunit protein uL13m Chain: K3
Molecule details ›
Chain: K3
Length: 178 amino acids
Theoretical weight: 20.72 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYD1 (Residues: 1-178; Coverage: 100%)
Gene name: MRPL13
Sequence domains: Ribosomal protein L13
Large ribosomal subunit protein uL14m Chain: L3
Molecule details ›
Chain: L3
Length: 145 amino acids
Theoretical weight: 15.97 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q6P1L8 (Residues: 1-145; Coverage: 100%)
Gene names: MRPL14, MRPL32, RPML32
Sequence domains: Ribosomal protein L14p/L23e
Large ribosomal subunit protein uL15m Chain: M3
Molecule details ›
Chain: M3
Length: 296 amino acids
Theoretical weight: 33.47 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9P015 (Residues: 1-296; Coverage: 100%)
Gene names: HSPC145, MRPL15
Sequence domains: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
Large ribosomal subunit protein uL16m Chain: N3
Molecule details ›
Chain: N3
Length: 251 amino acids
Theoretical weight: 28.5 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NX20 (Residues: 1-251; Coverage: 100%)
Gene names: MRPL16, PNAS-111
Sequence domains: Ribosomal protein L16p/L10e
Large ribosomal subunit protein bL17m Chain: O3
Molecule details ›
Chain: O3
Length: 175 amino acids
Theoretical weight: 20.08 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NRX2 (Residues: 1-175; Coverage: 100%)
Gene names: LIP2, MRPL17
Sequence domains: Ribosomal protein L17
Large ribosomal subunit protein uL18m Chain: P3
Molecule details ›
Chain: P3
Length: 180 amino acids
Theoretical weight: 20.61 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9H0U6 (Residues: 1-180; Coverage: 100%)
Gene names: HSPC071, MRPL18
Sequence domains: Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast
Large ribosomal subunit protein bL19m Chain: Q3
Molecule details ›
Chain: Q3
Length: 292 amino acids
Theoretical weight: 33.58 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P49406 (Residues: 1-292; Coverage: 100%)
Gene names: KIAA0104, MRPL15, MRPL19
Sequence domains: Ribosomal protein L19
Large ribosomal subunit protein bL20m Chain: R3
Molecule details ›
Chain: R3
Length: 149 amino acids
Theoretical weight: 17.48 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYC9 (Residues: 1-149; Coverage: 100%)
Gene name: MRPL20
Sequence domains: Ribosomal protein L20
Large ribosomal subunit protein bL21m Chain: S3
Molecule details ›
Chain: S3
Length: 205 amino acids
Theoretical weight: 22.85 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q7Z2W9 (Residues: 1-205; Coverage: 100%)
Gene name: MRPL21
Sequence domains: Ribosomal prokaryotic L21 protein
Large ribosomal subunit protein uL22m Chain: T3
Molecule details ›
Chain: T3
Length: 206 amino acids
Theoretical weight: 23.68 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NWU5 (Residues: 1-206; Coverage: 100%)
Gene names: HSPC158, MRPL22, MRPL25, RPML25
Sequence domains: Ribosomal protein L22p/L17e
Large ribosomal subunit protein uL23m Chain: U3
Molecule details ›
Chain: U3
Length: 153 amino acids
Theoretical weight: 17.81 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q16540 (Residues: 1-153; Coverage: 100%)
Gene names: L23MRP, MRPL23, RPL23L
Sequence domains: Ribosomal protein L23
Large ribosomal subunit protein uL24m Chain: V3
Molecule details ›
Chain: V3
Length: 216 amino acids
Theoretical weight: 24.95 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96A35 (Residues: 1-216; Coverage: 100%)
Gene name: MRPL24
Sequence domains:
Large ribosomal subunit protein bL27m Chain: W3
Molecule details ›
Chain: W3
Length: 148 amino acids
Theoretical weight: 16.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9P0M9 (Residues: 1-148; Coverage: 100%)
Gene names: HSPC250, MRPL27
Sequence domains: Ribosomal L27 protein
Large ribosomal subunit protein bL28m Chain: X3
Molecule details ›
Chain: X3
Length: 256 amino acids
Theoretical weight: 30.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13084 (Residues: 1-256; Coverage: 100%)
Gene names: MAAT1, MRPL28
Sequence domains: Ribosomal L28 family
Large ribosomal subunit protein uL29m Chain: Y3
Molecule details ›
Chain: Y3
Length: 250 amino acids
Theoretical weight: 29.51 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9HD33 (Residues: 1-250; Coverage: 100%)
Gene names: CGI-204, MRPL47, NCM1
Sequence domains: Mitochondrial 39-S ribosomal protein L47 (MRP-L47)
Large ribosomal subunit protein uL30m Chain: Z3
Molecule details ›
Chain: Z3
Length: 161 amino acids
Theoretical weight: 18.58 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8TCC3 (Residues: 1-161; Coverage: 100%)
Gene names: HSPC249, MRPL28, MRPL30, RPML28
Sequence domains: Ribosomal protein L30p/L7e
Large ribosomal subunit protein bL32m Chain: 03
Molecule details ›
Chain: 03
Length: 188 amino acids
Theoretical weight: 21.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYC8 (Residues: 1-188; Coverage: 100%)
Gene names: HSPC283, MRPL32
Sequence domains: Ribosomal L32p protein family
Large ribosomal subunit protein bL33m Chain: 13
Molecule details ›
Chain: 13
Length: 65 amino acids
Theoretical weight: 7.64 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75394 (Residues: 1-65; Coverage: 100%)
Gene names: C2orf1, MRPL33
Sequence domains: Ribosomal protein L33
Large ribosomal subunit protein bL34m Chain: 23
Molecule details ›
Chain: 23
Length: 92 amino acids
Theoretical weight: 10.18 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BQ48 (Residues: 1-92; Coverage: 100%)
Gene name: MRPL34
Sequence domains: Ribosomal protein L34
Large ribosomal subunit protein bL35m Chain: 33
Molecule details ›
Chain: 33
Length: 188 amino acids
Theoretical weight: 21.56 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NZE8 (Residues: 1-188; Coverage: 100%)
Gene names: BM-007, MRPL35
Sequence domains: Ribosomal protein L35
Large ribosomal subunit protein bL36m Chain: 43
Molecule details ›
Chain: 43
Length: 103 amino acids
Theoretical weight: 11.81 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9P0J6 (Residues: 1-103; Coverage: 100%)
Gene names: BRIP1, MRPL36
Sequence domains: Ribosomal protein L36
Large ribosomal subunit protein mL37 Chain: 53
Molecule details ›
Chain: 53
Length: 423 amino acids
Theoretical weight: 48.18 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BZE1 (Residues: 1-423; Coverage: 100%)
Gene names: HSPC235, MRPL2, MRPL37, RPML2
Sequence domains: Mitochondrial 28S ribosomal protein S30 (PDCD9)
Large ribosomal subunit protein mL38 Chain: 63
Molecule details ›
Chain: 63
Length: 380 amino acids
Theoretical weight: 44.66 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96DV4 (Residues: 1-380; Coverage: 100%)
Gene names: HSPC262, MRPL38
Sequence domains: Phosphatidylethanolamine-binding protein
Large ribosomal subunit protein mL39 Chain: 73
Molecule details ›
Chain: 73
Length: 338 amino acids
Theoretical weight: 38.76 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NYK5 (Residues: 1-338; Coverage: 100%)
Gene names: C21orf92, MRPL39, MRPL5, MSTP003, PRED22, RPML5
Large ribosomal subunit protein mL41 Chain: 93
Molecule details ›
Chain: 93
Length: 137 amino acids
Theoretical weight: 15.4 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8IXM3 (Residues: 1-137; Coverage: 100%)
Gene names: BMRP, MRPL27, MRPL41, PIG3, RPML27
Sequence domains: Mitochondrial ribosomal protein L27
Large ribosomal subunit protein mL42 Chain: a3
Molecule details ›
Chain: a3
Length: 142 amino acids
Theoretical weight: 16.69 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y6G3 (Residues: 1-142; Coverage: 100%)
Gene names: HSPC204, MRPL31, MRPL42, MRPS32, PTD007, RPML31
Sequence domains: Mitochondrial 28S ribosomal protein S32
Large ribosomal subunit protein mL43 Chain: b3
Molecule details ›
Chain: b3
Length: 215 amino acids
Theoretical weight: 23.46 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8N983 (Residues: 1-215; Coverage: 100%)
Gene name: MRPL43
Sequence domains: Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
Large ribosomal subunit protein mL44 Chain: c3
Molecule details ›
Chain: c3
Length: 332 amino acids
Theoretical weight: 37.58 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9H9J2 (Residues: 1-332; Coverage: 100%)
Gene name: MRPL44
Sequence domains:
Large ribosomal subunit protein mL45 Chain: d3
Molecule details ›
Chain: d3
Length: 306 amino acids
Theoretical weight: 35.4 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BRJ2 (Residues: 1-306; Coverage: 100%)
Gene name: MRPL45
Sequence domains: Tim44-like domain
Large ribosomal subunit protein mL46 Chain: e3
Molecule details ›
Chain: e3
Length: 279 amino acids
Theoretical weight: 31.75 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9H2W6 (Residues: 1-279; Coverage: 100%)
Gene names: C15orf4, LIECG2, MRPL46
Sequence domains: 39S mitochondrial ribosomal protein L46
Large ribosomal subunit protein mL48 Chain: f3
Molecule details ›
Chain: f3
Length: 212 amino acids
Theoretical weight: 23.97 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96GC5 (Residues: 1-212; Coverage: 100%)
Gene names: CGI-118, HSPC290, MRPL48
Sequence domains: Ribosomal protein S10p/S20e
Large ribosomal subunit protein mL49 Chain: g3
Molecule details ›
Chain: g3
Length: 166 amino acids
Theoretical weight: 19.23 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13405 (Residues: 1-166; Coverage: 100%)
Gene names: C11orf4, MRPL49, NOF1, OK/SW-cl.67
Sequence domains: Mitochondrial large subunit ribosomal protein (Img2)
Large ribosomal subunit protein mL50 Chain: h3
Molecule details ›
Chain: h3
Length: 158 amino acids
Theoretical weight: 18.35 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8N5N7 (Residues: 1-158; Coverage: 100%)
Gene name: MRPL50
Sequence domains: Ribosomal subunit 39S
Large ribosomal subunit protein mL51 Chain: i3
Molecule details ›
Chain: i3
Length: 128 amino acids
Theoretical weight: 15.13 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q4U2R6 (Residues: 1-128; Coverage: 100%)
Gene names: CDA09, HSPC241, MRP64, MRPL51
Sequence domains: Mitochondrial ribosomal subunit
Large ribosomal subunit protein mL52 Chain: j3
Molecule details ›
Chain: j3
Length: 123 amino acids
Theoretical weight: 13.68 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q86TS9 (Residues: 1-123; Coverage: 100%)
Gene name: MRPL52
Sequence domains: Mitoribosomal protein mL52
Large ribosomal subunit protein mL53 Chain: k3
Molecule details ›
Chain: k3
Length: 112 amino acids
Theoretical weight: 12.13 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96EL3 (Residues: 1-112; Coverage: 100%)
Gene name: MRPL53
Sequence domains: 39S ribosomal protein L53/MRP-L53
Large ribosomal subunit protein mL54 Chain: l3
Molecule details ›
Chain: l3
Length: 138 amino acids
Theoretical weight: 15.84 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q6P161 (Residues: 1-138; Coverage: 100%)
Gene name: MRPL54
Sequence domains: Mitochondrial ribosomal protein L37
Large ribosomal subunit protein mL55 Chain: m3
Molecule details ›
Chain: m3
Length: 128 amino acids
Theoretical weight: 15.16 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q7Z7F7 (Residues: 1-128; Coverage: 100%)
Gene names: MRPL55, UNQ5835/PRO19675
Sequence domains: Mitochondrial ribosomal protein L55
Large ribosomal subunit protein mL63 Chain: o3
Molecule details ›
Chain: o3
Length: 102 amino acids
Theoretical weight: 12.29 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BQC6 (Residues: 1-102; Coverage: 100%)
Gene names: MRP63, MRPL57
Sequence domains: Mitochondrial ribosome protein 63
Large ribosomal subunit protein mL62 Chain: p3
Molecule details ›
Chain: p3
Length: 206 amino acids
Theoretical weight: 23.67 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q14197 (Residues: 1-206; Coverage: 100%)
Gene names: DS1, ICT1, MRPL58
Sequence domains: RF-1 domain
Large ribosomal subunit protein mL64 Chain: q3
Molecule details ›
Chain: q3
Length: 222 amino acids
Theoretical weight: 25.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8TAE8 (Residues: 1-222; Coverage: 100%)
Gene names: GADD45GIP1, MRPL59, PLINP1, PRG6
Sequence domains: Growth arrest and DNA-damage-inducible proteins-interacting protein 1
Large ribosomal subunit protein mL66 Chain: r3
Molecule details ›
Chain: r3
Length: 196 amino acids
Theoretical weight: 22.22 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NVS2 (Residues: 1-196; Coverage: 100%)
Gene name: MRPS18A
Sequence domains: Ribosomal protein S18
Large ribosomal subunit protein mL65 Chains: s3, t3
Molecule details ›
Chains: s3, t3
Length: 467 amino acids
Theoretical weight: 52.81 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NP92 (Residues: 1-439; Coverage: 100%)
Gene names: BM-047, MRPS30, PDCD9
Sequence domains: Mitochondrial 28S ribosomal protein S30 (PDCD9)
Oxa1L tail Chain: A5
Molecule details ›
Chain: A5
Length: 28 amino acids
Theoretical weight: 2.4 KDa
Source organism: Homo sapiens
Small ribosomal subunit protein uS2m Chain: B6
Molecule details ›
Chain: B6
Length: 296 amino acids
Theoretical weight: 33.3 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y399 (Residues: 1-296; Coverage: 100%)
Gene names: CGI-91, MRPS2
Sequence domains: Ribosomal protein S2
Small ribosomal subunit protein uS3m Chain: C6
Molecule details ›
Chain: C6
Length: 167 amino acids
Theoretical weight: 19.05 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96EL2 (Residues: 1-167; Coverage: 100%)
Gene names: HSPC335, MRPS24
Sequence domains: Mitochondrial ribosome subunit S24
Small ribosomal subunit protein uS5m Chain: D6
Molecule details ›
Chain: D6
Length: 430 amino acids
Theoretical weight: 48.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82675 (Residues: 1-430; Coverage: 100%)
Gene name: MRPS5
Sequence domains:
Small ribosomal subunit protein bS6m Chain: E6
Molecule details ›
Chain: E6
Length: 125 amino acids
Theoretical weight: 14.25 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82932 (Residues: 1-125; Coverage: 100%)
Gene names: C21orf101, MRPS6, RPMS6
Sequence domains: Ribosomal protein S6
Small ribosomal subunit protein uS7m Chain: F6
Molecule details ›
Chain: F6
Length: 242 amino acids
Theoretical weight: 28.19 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y2R9 (Residues: 1-242; Coverage: 100%)
Gene name: MRPS7
Sequence domains: Ribosomal protein S7p/S5e
Small ribosomal subunit protein uS9m Chain: G6
Molecule details ›
Chain: G6
Length: 396 amino acids
Theoretical weight: 45.91 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82933 (Residues: 1-396; Coverage: 100%)
Gene names: MRPS9, RPMS9
Sequence domains: Ribosomal protein S9/S16
Small ribosomal subunit protein uS10m Chain: H6
Molecule details ›
Chain: H6
Length: 201 amino acids
Theoretical weight: 23.03 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82664 (Residues: 1-201; Coverage: 100%)
Gene names: MRPS10, MSTP040
Sequence domains: Ribosomal protein S10p/S20e
Small ribosomal subunit protein uS11m Chain: I6
Molecule details ›
Chain: I6
Length: 194 amino acids
Theoretical weight: 20.65 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82912 (Residues: 1-194; Coverage: 100%)
Gene names: HCC2, MRPS11, RPMS11
Sequence domains: Ribosomal protein S11
Small ribosomal subunit protein uS12m Chain: J6
Molecule details ›
Chain: J6
Length: 138 amino acids
Theoretical weight: 15.2 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O15235 (Residues: 1-138; Coverage: 100%)
Gene names: MRPS12, RPMS12, RPSM12
Sequence domains: Ribosomal protein S12/S23
Small ribosomal subunit protein uS14m Chain: K6
Molecule details ›
Chain: K6
Length: 128 amino acids
Theoretical weight: 15.17 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O60783 (Residues: 1-128; Coverage: 100%)
Gene name: MRPS14
Sequence domains: Ribosomal protein S14p/S29e
Small ribosomal subunit protein uS15m Chain: L6
Molecule details ›
Chain: L6
Length: 257 amino acids
Theoretical weight: 29.9 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82914 (Residues: 1-257; Coverage: 100%)
Gene names: DC37, MRPS15, RPMS15
Sequence domains: Ribosomal protein S15
Small ribosomal subunit protein bS16m Chain: M6
Molecule details ›
Chain: M6
Length: 137 amino acids
Theoretical weight: 15.37 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y3D3 (Residues: 1-137; Coverage: 100%)
Gene names: CGI-132, MRPS16, RPMS16
Sequence domains: Ribosomal protein S16
Small ribosomal subunit protein uS17m Chain: N6
Molecule details ›
Chain: N6
Length: 130 amino acids
Theoretical weight: 14.53 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y2R5 (Residues: 1-130; Coverage: 100%)
Gene names: HSPC011, MRPS17, RPMS17
Sequence domains: Ribosomal protein S17
Small ribosomal subunit protein mS40 Chain: O6
Molecule details ›
Chain: O6
Length: 258 amino acids
Theoretical weight: 29.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y676 (Residues: 1-258; Coverage: 100%)
Gene names: C6orf14, HSPC183, MRPS18B, PTD017
Sequence domains: Ribosomal protein S18
Small ribosomal subunit protein bS18m Chain: P6
Molecule details ›
Chain: P6
Length: 142 amino acids
Theoretical weight: 15.88 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y3D5 (Residues: 1-142; Coverage: 100%)
Gene names: CGI-134, MRPS18C
Sequence domains: Ribosomal protein S18
Small ribosomal subunit protein bS21m Chain: Q6
Molecule details ›
Chain: Q6
Length: 87 amino acids
Theoretical weight: 10.76 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82921 (Residues: 1-87; Coverage: 100%)
Gene names: MDS016, MRPS21, RPMS21
Sequence domains: Ribosomal protein S21
Small ribosomal subunit protein mS22 Chain: R6
Molecule details ›
Chain: R6
Length: 360 amino acids
Theoretical weight: 41.34 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82650 (Residues: 1-360; Coverage: 100%)
Gene names: C3orf5, GK002, MRPS22, RPMS22
Sequence domains: Mitochondrial 28S ribosomal protein S22
Small ribosomal subunit protein mS23 Chain: S6
Molecule details ›
Chain: S6
Length: 190 amino acids
Theoretical weight: 21.81 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y3D9 (Residues: 1-190; Coverage: 100%)
Gene names: CGI-138, HSPC329, MRPS23
Sequence domains: Mitochondrial ribosomal protein S23
Small ribosomal subunit protein mS25 Chain: T6
Molecule details ›
Chain: T6
Length: 173 amino acids
Theoretical weight: 20.15 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82663 (Residues: 1-173; Coverage: 100%)
Gene names: MRPS25, RPMS25
Sequence domains: Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
Small ribosomal subunit protein mS26 Chain: U6
Molecule details ›
Chain: U6
Length: 205 amino acids
Theoretical weight: 24.26 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYN8 (Residues: 1-205; Coverage: 100%)
Gene names: C20orf193, MRPS26, RPMS13
Sequence domains: Mitochondrial ribosome subunit S26
Small ribosomal subunit protein mS27 Chain: V6
Molecule details ›
Chain: V6
Length: 414 amino acids
Theoretical weight: 47.67 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q92552 (Residues: 1-414; Coverage: 100%)
Gene names: KIAA0264, MRPS27
Sequence domains: Mitochondrial 28S ribosomal protein S27
Small ribosomal subunit protein bS1m Chain: W6
Molecule details ›
Chain: W6
Length: 187 amino acids
Theoretical weight: 20.88 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y2Q9 (Residues: 1-187; Coverage: 100%)
Gene names: HSPC007, MRPS28, MRPS35
Sequence domains: Mitochondrial ribosomal protein MRP-S35
Small ribosomal subunit protein mS29 Chain: X6
Molecule details ›
Chain: X6
Length: 398 amino acids
Theoretical weight: 45.63 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P51398 (Residues: 1-398; Coverage: 100%)
Gene names: DAP3, MRPS29
Sequence domains: Mitochondrial ribosomal death-associated protein 3
Small ribosomal subunit protein mS31 Chain: Y6
Molecule details ›
Chain: Y6
Length: 395 amino acids
Theoretical weight: 45.39 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q92665 (Residues: 1-395; Coverage: 100%)
Gene names: IMOGN38, MRPS31
Sequence domains: Mitochondrial 28S ribosomal protein S31
Small ribosomal subunit protein mS33 Chain: Z6
Molecule details ›
Chain: Z6
Length: 106 amino acids
Theoretical weight: 12.66 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y291 (Residues: 1-106; Coverage: 100%)
Gene names: CGI-139, MRPS33, PTD003
Sequence domains: Mitochondrial ribosomal subunit S27
Small ribosomal subunit protein mS34 Chain: a6
Molecule details ›
Chain: a6
Length: 218 amino acids
Theoretical weight: 25.7 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82930 (Residues: 1-218; Coverage: 100%)
Gene name: MRPS34
Sequence domains: Mitochondrial 28S ribosomal protein S34
Small ribosomal subunit protein mS35 Chain: b6
Molecule details ›
Chain: b6
Length: 323 amino acids
Theoretical weight: 36.9 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82673 (Residues: 1-323; Coverage: 100%)
Gene names: HDCMD11P, MDS023, MRPS28, MRPS35, PSEC0213
Sequence domains: Mitochondrial ribosomal subunit protein
Small ribosomal subunit protein mS37 Chain: c6
Molecule details ›
Chain: c6
Length: 118 amino acids
Theoretical weight: 13.5 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96BP2 (Residues: 1-118; Coverage: 100%)
Gene names: C10orf34, CHCHD1, MRPS37
Sequence domains: CHCH domain
Small ribosomal subunit protein mS38 Chain: d6
Molecule details ›
Chain: d6
Length: 199 amino acids
Theoretical weight: 22.4 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NWT8 (Residues: 1-199; Coverage: 100%)
Gene names: AIP, AKIP, AURKAIP1, MRPS38
Sequence domains: Mitochondrial mRNA-processing protein COX24, C-terminal
Small ribosomal subunit protein mS39 Chain: e6
Molecule details ›
Chain: e6
Length: 689 amino acids
Theoretical weight: 78.65 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96EY7 (Residues: 1-689; Coverage: 100%)
Gene names: MRPS39, PTCD3, TRG15
Sequence domains:
Large ribosomal subunit protein mL40 Chain: A
Molecule details ›
Chain: A
Length: 206 amino acids
Theoretical weight: 24.53 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NQ50 (Residues: 1-206; Coverage: 100%)
Gene names: MRPL40, NLVCF, URIM
Sequence domains: Mitochondrial ribosomal protein L28
Elongation factor Tu, mitochondrial Chain: Z
Molecule details ›
Chain: Z
Length: 452 amino acids
Theoretical weight: 49.61 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P49411 (Residues: 4-455; Coverage: 99%)
Gene name: TUFM
Sequence domains:
Large ribosomal subunit protein uL1 Chain: n
Molecule details ›
Chain: n
Length: 229 amino acids
Theoretical weight: 24.87 KDa
Source organism: Thermus thermophilus HB27
UniProt:
  • Canonical: P27150 (Residues: 1-229; Coverage: 100%)
Gene names: rpl1, rplA
Sequence domains: Ribosomal protein L1p/L10e family
16S ribosomal RNA Chain: A3
Molecule details ›
Chain: A3
Length: 1559 nucleotides
Theoretical weight: 500.02 KDa
Sequence domains: Bacterial large subunit ribosomal RNA
mt-tRNAVal Chain: B3
Molecule details ›
Chain: B3
Length: 69 nucleotides
Theoretical weight: 22.02 KDa
Sequence domains: tRNA
RNA (5'-R(P*CP*A)-3') Chain: u3
Molecule details ›
Chain: u3
Length: 2 nucleotides
Theoretical weight: 589 Da
12S rRNA Chain: A6
Molecule details ›
Chain: A6
Length: 954 nucleotides
Theoretical weight: 306.14 KDa
Sequence domains: Bacterial small subunit ribosomal RNA
P tRNA Chains: 24, C
Molecule details ›
Chains: 24, C
Length: 73 nucleotides
Theoretical weight: 23.38 KDa
Sequence domains: tRNA
Messenger RNA Chain: i4
Molecule details ›
Chain: i4
Length: 10 nucleotides
Theoretical weight: 3.21 KDa
E tRNA Chain: j
Molecule details ›
Chain: j
Length: 76 nucleotides
Theoretical weight: 24.44 KDa
Sequence domains: tRNA

Ligands and Environments

9 bound ligands:
Ligand MG 128 x MG
Ligand SPD 1 x SPD
Ligand ZN 7 x ZN
Ligand GDP 1 x GDP
Ligand GCP 1 x GCP
Ligand NA 4 x NA
Ligand SO4 1 x SO4
Ligand MLI 3 x MLI
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.33Å
Relevant EMDB volumes: EMD-11642

Quick links

Citations

16 review citations

Mechanisms and regulation of protein synthesis in mitochondria.
Kummer et al. (2021)
15 more

2 mentions without citation

Maintaining mitochondrial ribosome function: The role of ribosome rescue and recycling factors.
Nadler et al. (2022)
1 more