7a3p

X-ray diffraction
3.19Å resolution

Crystal structure of dengue 3 virus envelope glycoprotein in complex with the scFv fragment of the broadly neutralizing human antibody EDE1 C10

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Envelope protein E Chains: A, B
Molecule details ›
Chains: A, B
Length: 428 amino acids
Theoretical weight: 46.82 KDa
Source organism: Dengue virus 3
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q07019 (Residues: 167-559; Coverage: 60%)
Sequence domains:
Single Chain Variable Fragment Chains: H, I
Molecule details ›
Chains: H, I
Length: 144 amino acids
Theoretical weight: 15.68 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
Single Chain Variable Fragment Chains: L, M
Molecule details ›
Chains: L, M
Length: 154 amino acids
Theoretical weight: 15.63 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P212121
Unit cell:
a: 53.744Å b: 101.412Å c: 249.236Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.243 0.24 0.284
Expression system: Drosophila melanogaster