› 7a33

X-ray diffraction
0.96Å resolution

Crystal structure of the c-Src SH3 domain mutant S94A-T98D-V111L-N113S-T114S at pH 3.0

Released:
DOI: 10.2210/pdb7a33/pdb
PDB 7a33 coloured by chain and viewed from the front.
PDB 7a33 coloured by chain and viewed from the side.
PDB 7a33 coloured by chain and viewed from the top.
Source organism: Gallus gallus
Entry authors: Camara-Artigas A, Plaza-Garrido M, Salinas-Garcia MC

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 60 amino acids
Theoretical weight: 6.72 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00523 (Residues: 82-141; Coverage: 11%)
Gene name: SRC
Sequence domains: SH3 domain

Ligands and Environments

2 bound ligands:
Ligand FMT 3 x FMT
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P21
Unit cell:
a: 23.203Å b: 63.262Å c: 30.073Å
α: 90° β: 95.65° γ: 90°
R-values:
R R work R free
0.119 0.119 0.134
Expression system: Escherichia coli BL21(DE3)

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