7a32

X-ray diffraction
1.15Å resolution

Crystal structure of the c-Src SH3 domain mutant S94A-T98D-V111L-N113S-T114S at pH 7.0

Released:
Source organism: Gallus gallus
Entry authors: Camara-Artigas A, Plaza-Garrido M, Salinas-Garcia MC

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 60 amino acids
Theoretical weight: 6.72 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00523 (Residues: 82-141; Coverage: 11%)
Gene name: SRC

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P3121
Unit cell:
a: 87.853Å b: 87.853Å c: 56.028Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.154 0.153 0.173
Expression system: Escherichia coli BL21(DE3)