X-ray diffraction
1.9Å resolution

Crystal structure of the Fyn SH3 domain mutant E129Q in space group C21 at pH 4.0

Source organism: Homo sapiens
Entry authors: Camara-Artigas A, Plaza-Garrido M, Salinas-Garcia MC

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein kinase Fyn Chains: A, B
Molecule details ›
Chains: A, B
Length: 60 amino acids
Theoretical weight: 6.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P06241 (Residues: 83-142; Coverage: 11%)
Gene name: FYN
Sequence domains: SH3 domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2
Unit cell:
a: 73.584Å b: 45.896Å c: 42.938Å
α: 90° β: 97.12° γ: 90°
R R work R free
0.21 0.207 0.261
Expression system: Escherichia coli BL21(DE3)