› 7z4v

X-ray diffraction
1.64Å resolution

Structure of Serine-Threonine kinase STK25 in complex with compound

Released:
DOI: 10.2210/pdb7z4v/pdb
PDB entry 7z4v coloured by chain, front view.
PDB entry 7z4v coloured by chain, side view.
PDB entry 7z4v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Targeting non-alcoholic fatty liver disease: Design, X-ray co-crystal structure and synthesis of 'first-in-kind' inhibitors of serine/threonine kinase25.
Kiyeleko S, Hocine S, Mautino G, Kuenemann M, Nawrotek A, Miallau L, Vuillard LM, Mirguet O, Kotschy A, Hanessian S
Bioorg Med Chem Lett 75 128950 (2022)
PMID: 36030002

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126324 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 25 Chain: A
Molecule details ›
Chain: A
Length: 297 amino acids
Theoretical weight: 33.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00506 (Residues: 1-294; Coverage: 69%)
Gene names: SOK1, STK25, YSK1
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand IB5 1 x IB5
Ligand EDO 1 x EDO
1 modified residue:
Ligand TPO 1 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: C2
Unit cell:
a: 126.2Å b: 46.413Å c: 57.954Å
α: 90° β: 90.56° γ: 90°
R-values:
R R work R free
0.247 0.245 0.283
Expression system: Escherichia coli

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