› 7w9u

X-ray diffraction
2.16Å resolution

Crystal Structure of Zn bound human Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase

Released:
DOI: 10.2210/pdb7w9u/pdb
PDB entry 7w9u coloured by chain, front view.
PDB entry 7w9u coloured by chain, side view.
PDB entry 7w9u coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Momin AA, Sandholu AS, Arold ST

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170202 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Focal adhesion kinase 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 164 amino acids
Theoretical weight: 18.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q05397 (Residues: 892-903, 904-1052; Coverage: 15%)
Gene names: FAK, FAK1, PTK2
Sequence domains: Focal adhesion targeting region

Ligands and Environments

1 bound ligand:
Ligand ZN 8 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: P1
Unit cell:
a: 49.2Å b: 52.45Å c: 53.37Å
α: 90.02° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.215 0.275
Expression system: Escherichia coli

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