Function and Biology Details
Reactions catalysed:
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
Protein scribble homolog and Envelope protein E (preferred)
PDBe Complex ID:
PDB-CPX-169549 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein scribble homolog
Molecule details ›
Chains: A, B
Length: 92 amino acids
Theoretical weight: 9.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: PDZ domain
Length: 92 amino acids
Theoretical weight: 9.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q14160 (Residues: 1002-1092; Coverage: 6%)
Sequence domains: PDZ domain
RNA-directed RNA polymerase NS5
Molecule details ›
Chain: C
Length: 8 amino acids
Theoretical weight: 931 Da
Source organism: Tick-borne encephalitis virus
Expression system: Not provided
UniProt:
Length: 8 amino acids
Theoretical weight: 931 Da
Source organism: Tick-borne encephalitis virus
Expression system: Not provided
UniProt:
- Canonical: Q01299 (Residues: 3407-3414; Coverage: 0%)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup:
R32
Expression systems:
- Escherichia coli
- Not provided
