› 7nwh

Electron Microscopy
4.1Å resolution

Mammalian pre-termination 80S ribosome with eRF1 and eRF3 bound by Blasticidin S.

Released:
DOI: 10.2210/pdb7nwh/pdb
PDB entry 7nwh coloured by chain, front view.
PDB entry 7nwh coloured by chain, side view.
PDB entry 7nwh coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
Powers KT, Stevenson-Jones F, Yadav SKN, Amthor B, Bufton JC, Borucu U, Shen D, Becker JP, Lavysh D, Hentze MW, Kulozik AE, Neu-Yilik G, Schaffitzel C
OpenAccess logo Nucleic Acids Res 49 7665-7679 (2021)
PMID: 34157102
Related structures: EMD-12632

Function and Biology Details

Reaction catalysed: 
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 84-mer (preferred)
PDBe Complex ID:
PDB-CPX-280964 (preferred)
Entry contents:
79 distinct polypeptide molecules
5 distinct RNA molecules
Macromolecules (84 distinct):
Large ribosomal subunit protein uL2 Chain: A
Molecule details ›
Chain: A
Length: 249 amino acids
Theoretical weight: 27.13 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: Q3T0S6 (Residues: 1-249; Coverage: 97%)
Gene name: RPL8
Sequence domains:
Large ribosomal subunit protein uL4 Chain: C
Molecule details ›
Chain: C
Length: 378 amino acids
Theoretical weight: 42.83 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SVW5 (Residues: 1-378; Coverage: 92%)
Gene name: RPL4
Sequence domains:
eL31 Chain: d
Molecule details ›
Chain: d
Length: 108 amino acids
Theoretical weight: 12.77 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein uS3 Chain: DD
Molecule details ›
Chain: DD
Length: 281 amino acids
Theoretical weight: 31.15 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TNM3 (Residues: 1-243; Coverage: 100%)
Gene name: RPS3
Sequence domains:
S29 Chain: dd
Molecule details ›
Chain: dd
Length: 56 amino acids
Theoretical weight: 6.69 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein uL18 Chain: D
Molecule details ›
Chain: D
Length: 296 amino acids
Theoretical weight: 34.35 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P19949 (Residues: 2-297; Coverage: 100%)
Gene name: RPL5
Large ribosomal subunit protein eL32 Chain: e
Molecule details ›
Chain: e
Length: 129 amino acids
Theoretical weight: 15.15 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TUN8 (Residues: 1-129; Coverage: 96%)
Gene name: RPL32
Sequence domains: Ribosomal protein L32
40S ribosomal protein S4 Chain: EE
Molecule details ›
Chain: EE
Length: 263 amino acids
Theoretical weight: 29.65 KDa
Source organism: Oryctolagus cuniculus
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein Chain: ee
Molecule details ›
Chain: ee
Length: 133 amino acids
Theoretical weight: 14.5 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1T8A2 (Residues: 1-133; Coverage: 100%)
Gene name: FAU
Sequence domains:
Large ribosomal subunit protein eL29 Chain: b
Molecule details ›
Chain: b
Length: 226 amino acids
Theoretical weight: 24.93 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SGR6 (Residues: 1-226; Coverage: 92%)
Gene name: RPL29
Sequence domains: Ribosomal L29e protein family
Large ribosomal subunit protein eL6 Chain: E
Molecule details ›
Chain: E
Length: 291 amino acids
Theoretical weight: 33.03 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SKF7 (Residues: 1-291; Coverage: 100%)
Gene name: RPL6
Sequence domains:
Large ribosomal subunit protein eL33 Chain: f
Molecule details ›
Chain: f
Length: 110 amino acids
Theoretical weight: 12.58 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SF08 (Residues: 1-110; Coverage: 100%)
Gene name: RPL35A
Sequence domains: Ribosomal protein L35Ae
Small ribosomal subunit protein uS7 Chain: FF
Molecule details ›
Chain: FF
Length: 204 amino acids
Theoretical weight: 22.91 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TFM5 (Residues: 1-204; Coverage: 100%)
Gene name: RPS5
Sequence domains: Ribosomal protein S7p/S5e
Small ribosomal subunit protein eS31 Chain: ff
Molecule details ›
Chain: ff
Length: 68 amino acids
Theoretical weight: 7.99 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P62992 (Residues: 83-150; Coverage: 44%)
Gene names: RPS27A, UBA80, UBCEP1
Sequence domains: Ribosomal protein S27a
Large ribosomal subunit protein uL30 Chain: F
Molecule details ›
Chain: F
Length: 249 amino acids
Theoretical weight: 29.51 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SV32 (Residues: 1-208; Coverage: 100%)
Gene name: RPL7
Sequence domains:
Large ribosomal subunit protein eL34 Chain: g
Molecule details ›
Chain: g
Length: 126 amino acids
Theoretical weight: 14.21 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TXG5 (Residues: 1-116; Coverage: 99%)
Gene name: RPL34
Sequence domains: Ribosomal protein L34e
40S ribosomal protein S3a Chain: BB
Molecule details ›
Chain: BB
Length: 264 amino acids
Theoretical weight: 29.94 KDa
Source organism: Oryctolagus cuniculus
40S ribosomal protein S6 Chain: GG
Molecule details ›
Chain: GG
Length: 263 amino acids
Theoretical weight: 30.2 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein RACK1 Chain: gg
Molecule details ›
Chain: gg
Length: 314 amino acids
Theoretical weight: 34.8 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: E9KL35 (Residues: 1-314; Coverage: 99%)
Sequence domains: WD domain, G-beta repeat
L7a Chain: G
Molecule details ›
Chain: G
Length: 242 amino acids
Theoretical weight: 27.61 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein uL29 Chain: h
Molecule details ›
Chain: h
Length: 123 amino acids
Theoretical weight: 14.57 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SIT5 (Residues: 1-123; Coverage: 100%)
Gene name: RPL35
Sequence domains: Ribosomal L29 protein
S7 Chain: HH
Molecule details ›
Chain: HH
Length: 191 amino acids
Theoretical weight: 21.85 KDa
Source organism: Oryctolagus cuniculus
40S ribosomal protein S27 Chain: bb
Molecule details ›
Chain: bb
Length: 84 amino acids
Theoretical weight: 9.48 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein uL6 Chain: H
Molecule details ›
Chain: H
Length: 190 amino acids
Theoretical weight: 21.63 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SWI6 (Residues: 1-190; Coverage: 99%)
Gene name: RPL9
Sequence domains: Ribosomal protein L6
60S ribosomal protein L36 Chain: i
Molecule details ›
Chain: i
Length: 107 amino acids
Theoretical weight: 12.32 KDa
Source organism: Oryctolagus cuniculus
40S ribosomal protein S8 Chain: II
Molecule details ›
Chain: II
Length: 208 amino acids
Theoretical weight: 24.26 KDa
Source organism: Oryctolagus cuniculus
Eukaryotic peptide chain release factor subunit 1 Chain: ii
Molecule details ›
Chain: ii
Length: 437 amino acids
Theoretical weight: 49.09 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P62497 (Residues: 1-437; Coverage: 100%)
Gene names: ERF1, ETF1, RF1
Sequence domains:
Large ribosomal subunit protein uL16 Chain: I
Molecule details ›
Chain: I
Length: 214 amino acids
Theoretical weight: 24.64 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: B7NZQ2 (Residues: 1-214; Coverage: 100%)
Gene name: RPL10
Sequence domains: Ribosomal protein L16p/L10e
Large ribosomal subunit protein eL37 Chain: j
Molecule details ›
Chain: j
Length: 97 amino acids
Theoretical weight: 11.11 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: U3KPD5 (Residues: 1-97; Coverage: 100%)
Gene name: RPL37
Sequence domains: Ribosomal protein L37e
Small ribosomal subunit protein uS4 Chain: JJ
Molecule details ›
Chain: JJ
Length: 194 amino acids
Theoretical weight: 22.66 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: A0A1S3APZ1 (Residues: 1-194; Coverage: 100%)
Gene name: RPS9
Sequence domains:
eRF3a Chain: jj
Molecule details ›
Chain: jj
Length: 428 amino acids
Theoretical weight: 48.06 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein uL5 Chain: J
Molecule details ›
Chain: J
Length: 176 amino acids
Theoretical weight: 20.09 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TUB8 (Residues: 3-178; Coverage: 99%)
Gene name: RPL11
Sequence domains:
L38 Chain: k
Molecule details ›
Chain: k
Length: 70 amino acids
Theoretical weight: 8.24 KDa
Source organism: Oryctolagus cuniculus
40S ribosomal protein S10 Chain: KK
Molecule details ›
Chain: KK
Length: 151 amino acids
Theoretical weight: 17.42 KDa
Source organism: Oryctolagus cuniculus
60S ribosomal protein L13 Chain: L
Molecule details ›
Chain: L
Length: 211 amino acids
Theoretical weight: 24.33 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein eL39 Chain: l
Molecule details ›
Chain: l
Length: 51 amino acids
Theoretical weight: 6.46 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TTN1 (Residues: 1-51; Coverage: 100%)
Gene name: LOC100343258
Sequence domains: Ribosomal L39 protein
40S ribosomal protein S11 Chain: LL
Molecule details ›
Chain: LL
Length: 158 amino acids
Theoretical weight: 18.51 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein eL14 Chain: M
Molecule details ›
Chain: M
Length: 218 amino acids
Theoretical weight: 23.87 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SZ12 (Residues: 1-218; Coverage: 100%)
Gene name: RPL14
Sequence domains: Ribosomal protein L14
60S RIBOSOMAL PROTEIN EL40 Chain: m
Molecule details ›
Chain: m
Length: 128 amino acids
Theoretical weight: 14.7 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein eS12 Chain: MM
Molecule details ›
Chain: MM
Length: 123 amino acids
Theoretical weight: 13.71 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SFR8 (Residues: 10-132; Coverage: 93%)
Gene name: RPS12
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein eL15 Chain: N
Molecule details ›
Chain: N
Length: 204 amino acids
Theoretical weight: 24.21 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1T0C1 (Residues: 1-204; Coverage: 100%)
Gene name: RPL15
Sequence domains: Ribosomal L15
Small ribosomal subunit protein eS32 Chain: n
Molecule details ›
Chain: n
Length: 25 amino acids
Theoretical weight: 3.47 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: A0A087WNH4 (Residues: 1-25; Coverage: 100%)
Gene name: RPL41
Sequence domains: Ribosomal protein L41
ribosomal protein uS15 Chain: NN
Molecule details ›
Chain: NN
Length: 150 amino acids
Theoretical weight: 17.19 KDa
Source organism: Oryctolagus cuniculus
60S RIBOSOMAL PROTEIN UL13 Chain: O
Molecule details ›
Chain: O
Length: 203 amino acids
Theoretical weight: 23.53 KDa
Source organism: Oryctolagus cuniculus
eL42 Chain: o
Molecule details ›
Chain: o
Length: 142 amino acids
Theoretical weight: 16.17 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein uS11 Chain: OO
Molecule details ›
Chain: OO
Length: 156 amino acids
Theoretical weight: 16.92 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1T1F0 (Residues: 1-151; Coverage: 100%)
Gene name: RPS14
Sequence domains: Ribosomal protein S11
uL22 Chain: P
Molecule details ›
Chain: P
Length: 199 amino acids
Theoretical weight: 23.06 KDa
Source organism: Oryctolagus cuniculus
ribosomal protein eL43 Chain: p
Molecule details ›
Chain: p
Length: 109 amino acids
Theoretical weight: 12.01 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein uS19 Chain: PP
Molecule details ›
Chain: PP
Length: 145 amino acids
Theoretical weight: 17.05 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1U0Q2 (Residues: 1-145; Coverage: 100%)
Gene name: RPS15
Sequence domains: Ribosomal protein S19
eL18 Chain: Q
Molecule details ›
Chain: Q
Length: 188 amino acids
Theoretical weight: 21.7 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein eL28 Chain: r
Molecule details ›
Chain: r
Length: 137 amino acids
Theoretical weight: 15.78 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1U7L1 (Residues: 1-137; Coverage: 100%)
Gene name: RPL28
Sequence domains: Ribosomal L28e protein family
Ribosomal protein S16 Chain: QQ
Molecule details ›
Chain: QQ
Length: 158 amino acids
Theoretical weight: 17.72 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein eL19 Chain: R
Molecule details ›
Chain: R
Length: 196 amino acids
Theoretical weight: 23.54 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: Q3T0W9 (Residues: 1-196; Coverage: 100%)
Gene name: RPL19
Sequence domains: Ribosomal protein L19e
Large ribosomal subunit protein uL10 Chain: s
Molecule details ›
Chain: s
Length: 318 amino acids
Theoretical weight: 34.38 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SPK4 (Residues: 1-318; Coverage: 100%)
Gene name: RPLP0
Sequence domains:
Small ribosomal subunit protein eS17 Chain: RR
Molecule details ›
Chain: RR
Length: 145 amino acids
Theoretical weight: 16.78 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: S7Q348 (Residues: 1-145; Coverage: 100%)
Gene name: D623_10013203
Sequence domains: Ribosomal S17
Large ribosomal subunit protein eL20 Chain: S
Molecule details ›
Chain: S
Length: 176 amino acids
Theoretical weight: 20.83 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: A0A287APR1 (Residues: 49-224; Coverage: 79%)
Gene name: RPL18A
Sequence domains: Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A
uL12 Chain: t
Molecule details ›
Chain: t
Length: 196 amino acids
Theoretical weight: 21.43 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein uS13 Chain: SS
Molecule details ›
Chain: SS
Length: 152 amino acids
Theoretical weight: 17.76 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TPG3 (Residues: 1-152; Coverage: 100%)
Gene name: RPS18
Sequence domains: Ribosomal protein S13/S18
Large ribosomal subunit protein eL21 Chain: T
Molecule details ›
Chain: T
Length: 160 amino acids
Theoretical weight: 18.61 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SHQ2 (Residues: 1-160; Coverage: 100%)
Gene name: RPL21
Sequence domains: Ribosomal protein L21e
eS19 Chain: TT
Molecule details ›
Chain: TT
Length: 145 amino acids
Theoretical weight: 16.11 KDa
Source organism: Oryctolagus cuniculus
L22 Chain: U
Molecule details ›
Chain: U
Length: 128 amino acids
Theoretical weight: 14.8 KDa
Source organism: Oryctolagus cuniculus
40S ribosomal protein S20 Chain: UU
Molecule details ›
Chain: UU
Length: 118 amino acids
Theoretical weight: 13.27 KDa
Source organism: Oryctolagus cuniculus
eL14 Chain: V
Molecule details ›
Chain: V
Length: 132 amino acids
Theoretical weight: 14.1 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein eS21 Chain: VV
Molecule details ›
Chain: VV
Length: 83 amino acids
Theoretical weight: 9.12 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: Q32PB8 (Residues: 1-83; Coverage: 100%)
Gene name: RPS21
Sequence domains: Ribosomal protein S21e
Large ribosomal subunit protein eL24 Chain: W
Molecule details ›
Chain: W
Length: 134 amino acids
Theoretical weight: 15.54 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: A0A061I3X8 (Residues: 1-134; Coverage: 100%)
Gene name: H671_4g12624
Sequence domains: Ribosomal protein L24e
Ribosomal protein S15a Chain: WW
Molecule details ›
Chain: WW
Length: 139 amino acids
Theoretical weight: 15.78 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein uL23 Chain: X
Molecule details ›
Chain: X
Length: 156 amino acids
Theoretical weight: 17.77 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SE76 (Residues: 1-156; Coverage: 100%)
Gene name: RPL23A
Sequence domains:
Small ribosomal subunit protein uS12 Chain: XX
Molecule details ›
Chain: XX
Length: 142 amino acids
Theoretical weight: 15.76 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SZ47 (Residues: 1-142; Coverage: 99%)
Gene name: RPS23
Sequence domains: Ribosomal protein S12/S23
Large ribosomal subunit protein uL24 Chain: Y
Molecule details ›
Chain: Y
Length: 134 amino acids
Theoretical weight: 15.89 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SQH0 (Residues: 1-134; Coverage: 92%)
Gene name: RPL26
Sequence domains:
40S ribosomal protein S24 Chain: YY
Molecule details ›
Chain: YY
Length: 146 amino acids
Theoretical weight: 17.01 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein eL27 Chain: Z
Molecule details ›
Chain: Z
Length: 136 amino acids
Theoretical weight: 15.84 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TXF6 (Residues: 1-136; Coverage: 100%)
Gene name: RPL27
Sequence domains:
Small ribosomal subunit protein eS25 Chain: ZZ
Molecule details ›
Chain: ZZ
Length: 122 amino acids
Theoretical weight: 13.45 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TDB3 (Residues: 3-124; Coverage: 98%)
Gene name: RPS25
Sequence domains: S25 ribosomal protein
Large ribosomal subunit protein uL15 Chain: a
Molecule details ›
Chain: a
Length: 147 amino acids
Theoretical weight: 16.49 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SNY0 (Residues: 2-148; Coverage: 99%)
Gene name: RPL27A
Sequence domains: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
40S_SA_C domain-containing protein Chain: AA
Molecule details ›
Chain: AA
Length: 295 amino acids
Theoretical weight: 32.96 KDa
Source organism: Oryctolagus cuniculus
40S ribosomal protein S26 Chain: aa
Molecule details ›
Chain: aa
Length: 117 amino acids
Theoretical weight: 13.15 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein uL3 Chain: B
Molecule details ›
Chain: B
Length: 402 amino acids
Theoretical weight: 45.98 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TL06 (Residues: 2-403; Coverage: 100%)
Gene name: RPL3
Sequence domains: Ribosomal protein L3
Large ribosomal subunit protein eL30 Chain: c
Molecule details ›
Chain: c
Length: 115 amino acids
Theoretical weight: 12.81 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TDL2 (Residues: 1-115; Coverage: 100%)
Gene name: RPL30
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
40S ribosomal protein S2 Chain: CC
Molecule details ›
Chain: CC
Length: 259 amino acids
Theoretical weight: 28 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein eS28 Chain: cc
Molecule details ›
Chain: cc
Length: 69 amino acids
Theoretical weight: 7.84 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TIB4 (Residues: 1-69; Coverage: 100%)
Gene name: RPS28
Sequence domains: Ribosomal protein S28e
Messenger RNA Chain: hh
Molecule details ›
Chain: hh
Length: 15 nucleotides
Theoretical weight: 4.75 KDa
28S ribosomal RNA Chain: 5
Molecule details ›
Chain: 5
Length: 3705 nucleotides
Theoretical weight: 1199.7 KDa
Sequence domains: Eukaryotic large subunit ribosomal RNA
5S ribosomal RNA Chain: 7
Molecule details ›
Chain: 7
Length: 120 nucleotides
Theoretical weight: 38.69 KDa
Sequence domains: 5S ribosomal RNA
5.8S ribosomal RNA Chain: 8
Molecule details ›
Chain: 8
Length: 151 nucleotides
Theoretical weight: 48.55 KDa
Sequence domains: 5.8S ribosomal RNA
18S Ribosomal RNA Chain: 9
Molecule details ›
Chain: 9
Length: 1779 nucleotides
Theoretical weight: 573.84 KDa
Sequence domains: Eukaryotic small subunit ribosomal RNA

Ligands and Environments

4 bound ligands:
Ligand ZN 8 x ZN
Ligand MG 281 x MG
Ligand GCP 1 x GCP
Ligand BLS 1 x BLS
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.1Å
Relevant EMDB volumes: EMD-12632

Quick links

Citations

2 review citations

No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors.
Mailliot et al. (2022)
1 more

2 mentions without citation

Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
Powers et al. (2021)
1 more