› 7api

X-ray diffraction
3Å resolution

THE S VARIANT OF HUMAN ALPHA1-ANTITRYPSIN, STRUCTURE AND IMPLICATIONS FOR FUNCTION AND METABOLISM

Released:
DOI: 10.2210/pdb7api/pdb
PDB entry 7api coloured by chain, front view.
PDB entry 7api coloured by chain, side view.
PDB entry 7api coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolism.
Engh R, Löbermann H, Schneider M, Wiegand G, Huber R, Laurell CB
Protein Eng 2 407-15 (1989)
PMID: 2785270

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133785 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Alpha-1-antitrypsin Chain: A
Molecule details ›
Chain: A
Length: 347 amino acids
Theoretical weight: 39.11 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01009 (Residues: 36-382; Coverage: 88%)
Gene names: AAT, PI, PRO0684, PRO2209, SERPINA1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:
Short peptide from AAT Chain: B
Molecule details ›
Chain: B
Length: 36 amino acids
Theoretical weight: 4.14 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01009 (Residues: 383-418; Coverage: 9%)
Gene names: AAT, PI, PRO0684, PRO2209, SERPINA1

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand CYS 1 x CYS
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P43212
Unit cell:
a: 120.5Å b: 120.5Å c: 113.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.193 not available
Expression system: Not provided

Quick links

Citations

8 review citations

Natural protein proteinase inhibitors and their interaction with proteinases.
Bode et al. (1992)
7 more

14 mentions without citation

An overview of the serpin superfamily.
Law et al. (2006)
13 more