X-ray diffraction
1.6Å resolution

Crystal structure of OXA-10loop24 in complex with meropenem

Source organism: Escherichia coli
Entry authors: Tassone G, Di Pisa F, Benvenuti M, De Luca F, Pozzi C, Mangani S, Docquier JD

Function and Biology Details

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Beta-lactamase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 243 amino acids
Theoretical weight: 27.38 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli DH5[alpha]
  • Canonical: Q7BNC2 (Residues: 21-266; Coverage: 98%)
Gene names: G5603_26575, HND12_29335, HND12_30745, HND12_30755, blaOXA-10, blaoxa-10, oxa-10
Sequence domains: Penicillin binding protein transpeptidase domain

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P32
Unit cell:
a: 80.64Å b: 80.64Å c: 152.29Å
α: 90° β: 90° γ: 120°
R R work R free
0.17 0.169 0.207
Expression system: Escherichia coli DH5[alpha]