6zp3

X-ray diffraction
1.8Å resolution

Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 2-Methylindole-3-acetic acid

Released:

Function and Biology Details

Reaction catalysed:
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin glutathione reductase Chain: A
Molecule details ›
Chain: A
Length: 598 amino acids
Theoretical weight: 65.11 KDa
Source organism: Schistosoma mansoni
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A3Q0KFL1 (Residues: 35-630; Coverage: 95%)
Sequence domains:

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-3
Spacegroup: C2
Unit cell:
a: 141.849Å b: 102.186Å c: 58.572Å
α: 90° β: 112.94° γ: 90°
R-values:
R R work R free
0.174 0.172 0.206
Expression system: Escherichia coli