› 6zp1

Electron Microscopy
3.3Å resolution

Structure of SARS-CoV-2 Spike Protein Trimer (K986P, V987P, single Arg S1/S2 cleavage site) in Closed State

Released:
DOI: 10.2210/pdb6zp1/pdb
PDB 6zp1 coloured by chain and viewed from the front.
PDB 6zp1 coloured by chain and viewed from the side.
PDB 6zp1 coloured by chain and viewed from the top.
Source organism: Severe acute respiratory syndrome coronavirus 2
Primary publication:
A thermostable, closed SARS-CoV-2 spike protein trimer.
Xiong X, Qu K, Ciazynska KA, Hosmillo M, Carter AP, Ebrahimi S, Ke Z, Scheres SHW, Bergamaschi L, Grice GL, Zhang Y, Nathan JA, Baker S, James LC, Baxendale HE, Goodfellow I, Doffinger R, Briggs JAG
Nat Struct Mol Biol 27 934-941 (2020)
PMID: 32737467
Related structures: EMD-11333

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1247 amino acids
Theoretical weight: 138.28 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 14-1211; Coverage: 95%)
Gene names: 2, S
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 33 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-11333
Expression system: Homo sapiens

Quick links

Citations

24 review citations

Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy.
Zhang et al. (2021)
23 more

12 mentions without citation

Man-Specific, GalNAc/T/Tn-Specific and Neu5Ac-Specific Seaweed Lectins as Glycan Probes for the SARS-CoV-2 (COVID-19) Coronavirus.
Barre et al. (2020)
11 more