› 6zoy

Electron Microscopy
3.1Å resolution

Structure of Disulphide-stabilized SARS-CoV-2 Spike Protein Trimer (x1 disulphide-bond mutant, S383C, D985C, K986P, V987P, single Arg S1/S2 cleavage site) in Closed State

Released:
DOI: 10.2210/pdb6zoy/pdb
PDB 6zoy coloured by chain and viewed from the front.
PDB 6zoy coloured by chain and viewed from the side.
PDB 6zoy coloured by chain and viewed from the top.
Source organism: Severe acute respiratory syndrome coronavirus 2
Primary publication:
A thermostable, closed SARS-CoV-2 spike protein trimer.
Xiong X, Qu K, Ciazynska KA, Hosmillo M, Carter AP, Ebrahimi S, Ke Z, Scheres SHW, Bergamaschi L, Grice GL, Zhang Y, Nathan JA, Baker S, James LC, Baxendale HE, Goodfellow I, Doffinger R, Briggs JAG
Nat Struct Mol Biol 27 934-941 (2020)
PMID: 32737467
Related structures: EMD-11330

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1247 amino acids
Theoretical weight: 138.28 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 14-1211; Coverage: 95%)
Gene names: 2, S
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 36 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-11330
Expression system: Homo sapiens

Quick links

Citations

4 review citations

COVID-19: The Effect of Host Genetic Variations on Host-Virus Interactions.
Chakravarty S. (2021)
3 more