› 6zl6

X-ray diffraction
1.7Å resolution

Crystal Structure of UDP-Glucuronic acid 4-epimerase from Bacillus cereus in complex with UDP and NAD

Released:
DOI: 10.2210/pdb6zl6/pdb
PDB 6zl6 coloured by chain and viewed from the front.
PDB 6zl6 coloured by chain and viewed from the side.
PDB 6zl6 coloured by chain and viewed from the top.
Source organism: Bacillus cereus HuA2-4
Primary publication:
Crystallographic snapshots of UDP-glucuronic acid 4-epimerase ligand binding, rotation, and reduction.
Iacovino LG, Savino S, Borg AJE, Binda C, Nidetzky B, Mattevi A
J Biol Chem 295 12461-12473 (2020)
PMID: 32661196

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epimerase domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 327 amino acids
Theoretical weight: 36.53 KDa
Source organism: Bacillus cereus HuA2-4
Expression system: Escherichia coli

Ligands and Environments

2 bound ligands:
Ligand UDP 2 x UDP
Ligand NAD 2 x NAD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P1
Unit cell:
a: 42.482Å b: 58.56Å c: 64.904Å
α: 96.77° β: 98.41° γ: 110.3°
R-values:
R R work R free
0.172 0.171 0.202
Expression system: Escherichia coli

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