Electron Microscopy
3.93Å resolution

Cryo-EM structure of DNA-PKcs:Ku80ct194


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DNA-dependent protein kinase catalytic subunit Chain: A
Molecule details ›
Chain: A
Length: 4156 amino acids
Theoretical weight: 472.06 KDa
Source organism: Homo sapiens
  • Canonical: P78527 (Residues: 1-4128; Coverage: 100%)
Gene names: HYRC, HYRC1, PRKDC
Sequence domains:
X-ray repair cross-complementing protein 5 Chain: B
Molecule details ›
Chain: B
Length: 192 amino acids
Theoretical weight: 21.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P13010 (Residues: 541-732; Coverage: 26%)
Gene names: G22P2, XRCC5
Sequence domains: Ku C terminal domain like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.93Å
Relevant EMDB volumes: EMD-11215
Expression system: Escherichia coli