› 6zh1

X-ray diffraction
2.2Å resolution

Crystal structure of complex between FH19-20 and FhbA protein from Borrelia hermsii

Released:
DOI: 10.2210/pdb6zh1/pdb
PDB 6zh1 coloured by chain and viewed from the front.
PDB 6zh1 coloured by chain and viewed from the side.
PDB 6zh1 coloured by chain and viewed from the top.
Source organisms:
Primary publication:
Mechanism of Borrelia immune evasion by FhbA-related proteins.
Kogan K, Haapasalo K, Kotila T, Moore R, Lappalainen P, Goldman A, Meri T
PLoS Pathog. 18 e1010338-e1010338 (2022)
PMID: 35303742

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Factor H binding protein Chain: A
Molecule details ›
Chain: A
Length: 186 amino acids
Theoretical weight: 22.15 KDa
Source organism: Borrelia hermsii YOR
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: W5SB08 (Residues: 17-17, 31-202; Coverage: 86%)
Gene name: BHY_1174
Complement factor H Chain: B
Molecule details ›
Chain: B
Length: 133 amino acids
Theoretical weight: 15.08 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P08603 (Residues: 1104-1231; Coverage: 11%)
Gene names: CFH, HF, HF1, HF2
Sequence domains: Sushi repeat (SCR repeat)

Ligands and Environments

2 bound ligands:
Ligand EDO 4 x EDO
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 43.273Å b: 60.327Å c: 145.681Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.19 0.24
Expression systems:
  • Escherichia coli BL21(DE3)
  • Komagataella pastoris

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