› 6zgu

X-ray diffraction
2.18Å resolution

Crystal structure of a MFS transporter with bound 3-(2-methylphenyl)propanoic acid at 2.41 Angstroem resolution

Released:
DOI: 10.2210/pdb6zgu/pdb
PDB 6zgu coloured by chain and viewed from the front.
PDB 6zgu coloured by chain and viewed from the side.
PDB 6zgu coloured by chain and viewed from the top.
Source organism: Syntrophobacter fumaroxidans MPOB
Primary publication:
The making of a potent L-lactate transport inhibitor
Bosshart PD, Kalbermatter D, Bonetti S, Fotiadis D
Commun Chem 4 128- (2021)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L-lactate transporter Chains: A, B
Molecule details ›
Chains: A, B
Length: 420 amino acids
Theoretical weight: 44.8 KDa
Source organism: Syntrophobacter fumaroxidans MPOB
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0LNN5 (Residues: 1-412; Coverage: 100%)
Gene name: Sfum_3364
Sequence domains: Major Facilitator Superfamily

Ligands and Environments

1 bound ligand:
Ligand 02Q 2 x 02Q
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21212
Unit cell:
a: 102.048Å b: 199.703Å c: 61.616Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.216 0.244
Expression system: Escherichia coli BL21(DE3)

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