› 6zgh

Electron Microscopy
6.8Å resolution

Furin Cleaved Spike Protein of SARS-CoV-2 in Intermediate Conformation

Released:
DOI: 10.2210/pdb6zgh/pdb
PDB 6zgh coloured by chain and viewed from the front.
PDB 6zgh coloured by chain and viewed from the side.
PDB 6zgh coloured by chain and viewed from the top.
Source organism: Severe acute respiratory syndrome coronavirus 2
Primary publication:
SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects.
Wrobel AG, Benton DJ, Xu P, Roustan C, Martin SR, Rosenthal PB, Skehel JJ, Gamblin SJ
Nat Struct Mol Biol 27 763-767 (2020)
PMID: 32647346
Related structures: EMD-11206

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1287 amino acids
Theoretical weight: 142.41 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 6.8Å
Relevant EMDB volumes: EMD-11206
Expression system: Homo sapiens

Quick links

Citations

9 review citations

A Biochemical Perspective of the Nonstructural Proteins (NSPs) and the Spike Protein of SARS CoV-2.
Yoshimoto FK. (2021)
8 more