Structure analysis

Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound Saracatinib (AZD0530)

X-ray diffraction
2.67Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1
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Multimeric state: monomeric

Binding statistics and energies are not available for this assembly
Assembly 2
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Multimeric state: monomeric

Binding statistics and energies are not available for this assembly
Assembly 3
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Multimeric state: monomeric

Binding statistics and energies are not available for this assembly
Assembly 4 (preferred)
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Multimeric state: monomeric

Binding statistics and energies are not available for this assembly

Macromolecules

Chains: A, B, C, D
Length: 301 amino acids
Theoretical weight: 34.54 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q04771 (Residues: 201-499; Coverage: 61%)
Gene names: ACVR1, ACVRLK2
Pfam: Protein tyrosine and serine/threonine kinase

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