X-ray diffraction
1.6Å resolution

High resolution structure of VEGF-A 12:107 crystallized in tetragonal form

Source organism: Homo sapiens
Entry authors: Gaucher J-F, Broussy S, Reille-Seroussi M

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Vascular endothelial growth factor A Chains: V, W
Molecule details ›
Chains: V, W
Length: 96 amino acids
Theoretical weight: 11.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P15692 (Residues: 39-133; Coverage: 46%)
Gene names: VEGF, VEGFA
Sequence domains: PDGF/VEGF domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P41
Unit cell:
a: 88.34Å b: 88.34Å c: 40.489Å
α: 90° β: 90° γ: 90°
R R work R free
0.165 0.164 0.186
Expression system: Escherichia coli BL21(DE3)