› 6z8p

X-ray diffraction
1.55Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 2 Chain: AAA
Molecule details ›
Chain: AAA
Length: 115 amino acids
Theoretical weight: 13.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25440 (Residues: 344-455; Coverage: 14%)
Gene names: BRD2, KIAA9001, RING3
Sequence domains: Bromodomain

Ligands and Environments

3 bound ligands:
Ligand EDO 3 x EDO
Ligand 1PG 1 x 1PG
Ligand QC8 1 x QC8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P21212
Unit cell:
a: 71.877Å b: 52.473Å c: 32.07Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.165 0.195
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Improved methods for targeting epigenetic reader domains of acetylated and methylated lysine.
Engelberg et al. (2021)
3 more

1 mention without citation

GSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family.
Preston et al. (2020)