› 6z6y

X-ray diffraction
1.34Å resolution

Galectin-8 N-terminal domain in complex with a sulfatide mimicking a sphingolipid

Released:
DOI: 10.2210/pdb6z6y/pdb
PDB 6z6y coloured by chain and viewed from the front.
PDB 6z6y coloured by chain and viewed from the side.
PDB 6z6y coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Probing sulfatide-tissue lectin recognition with functionalized glycodendrimersomes.
Murphy PV, Romero A, Xiao Q, Ludwig AK, Jogula S, Shilova NV, Singh T, Gabba A, Javed B, Zhang D, Medrano FJ, Kaltner H, Kopitz J, Bovin NV, Wu AM, Klein ML, Percec V, Gabius HJ
iScience 24 101919 (2021)
PMID: 33409472

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galectin-8 Chain: A
Molecule details ›
Chain: A
Length: 163 amino acids
Theoretical weight: 18.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00214 (Residues: 1-163; Coverage: 51%)
Gene name: LGALS8
Sequence domains: Galactoside-binding lectin

Ligands and Environments

3 bound ligands:
Ligand QAH 1 x QAH
Ligand ACT 6 x ACT
Ligand PGE 1 x PGE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: C2
Unit cell:
a: 110.64Å b: 40.066Å c: 40.701Å
α: 90° β: 99.8° γ: 90°
R-values:
R R work R free
0.173 0.171 0.213
Expression system: Escherichia coli

Quick links

Citations

1 review citation

What Cyto- and Histochemistry Can Do to Crack the Sugar Code.
Habermann et al. (2021)
1 other article