6z55

X-ray diffraction
1.7Å resolution

Crystal structure of CLK3 in complex with macrocycle ODS2004070

Released:
Source organism: Homo sapiens
Entry authors: Chaikuad A, Benderitter P, Hoflack J, Denis A, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity protein kinase CLK3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 360 amino acids
Theoretical weight: 42.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49761 (Residues: 275-632; Coverage: 56%)
Gene name: CLK3
Sequence domains: Protein kinase domain

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2
Unit cell:
a: 96.73Å b: 131.36Å c: 83.8Å
α: 90° β: 107.8° γ: 90°
R-values:
R R work R free
0.158 0.156 0.195
Expression system: Escherichia coli BL21(DE3)