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Human wtSTING in complex with 3',3'-c-di-AMP

X-ray diffraction
2.5Å resolution
PDB entry 6z15 coloured by chain, front view.
PDB entry 6z15 coloured by chain, side view.
PDB entry 6z15 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: STING complex
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Multimeric state: homo dimer
PDBe Complex ID: PDB-CPX-183240
Complex Portal ID: CPX-2127

Macromolecules

Stimulator of interferon genes protein
Chain: A
Length: 204 amino acids
Theoretical weight: 23.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86WV6 (Residues: 140-343; Coverage: 54%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Pfam: Transmembrane protein 173
InterPro:
Stimulator of interferon genes protein in PDB entry 6z15, assembly 1, front view.
Stimulator of interferon genes protein in PDB entry 6z15, assembly 1, side view.
Stimulator of interferon genes protein in PDB entry 6z15, assembly 1, top view.
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