6z10

X-ray diffraction
2.27Å resolution

Crystal structure of a humanized (K18E, K269N) rat succinate receptor SUCNR1 (GPR91) in complex with a nanobody and antagonist

Released:

Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Succinate receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 342 amino acids
Theoretical weight: 39.83 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6IYF9 (Residues: 2-317; Coverage: 100%)
Gene names: Gpr91, Sucnr1
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Nanobody6 Chain: B
Molecule details ›
Chain: B
Length: 142 amino acids
Theoretical weight: 15.53 KDa
Source organism: Vicugna pacos
Expression system: Spodoptera frugiperda

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 76.839Å b: 151.003Å c: 68.211Å
α: 90° β: 112.29° γ: 90°
R-values:
R R work R free
0.205 0.204 0.223
Expression system: Spodoptera frugiperda