6z0z

X-ray diffraction
2.5Å resolution

Human wtSTING in complex with 3',3'-c-(2'FdAMP-2'FdAMP)

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chain: A
Molecule details ›
Chain: A
Length: 204 amino acids
Theoretical weight: 23.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86WV6 (Residues: 140-343; Coverage: 54%)
Gene names: ERIS, MITA, STING, STING1, TMEM173

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P43212
Unit cell:
a: 67.174Å b: 67.174Å c: 136.047Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.227
Expression system: Escherichia coli