6z0x

X-ray diffraction
3.1Å resolution

HtrA1 inactive protease domain S328A with CARASIL mutations D174R R274Q

Released:
Source organism: Homo sapiens
Entry authors: Vetter IR, Stege P, Ingendahl L, Ehrmann M

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease HTRA1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 236 amino acids
Theoretical weight: 25.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92743 (Residues: 161-375; Coverage: 47%)
Gene names: HTRA, HTRA1, PRSS11
Sequence domains: Trypsin-like peptidase domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P63
Unit cell:
a: 103.52Å b: 103.52Å c: 147.34Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.226 0.224 0.274
Expression system: Escherichia coli