› 6z0i

Solution NMR

Structure of the TREM2 transmembrane helix in complex with DAP12 in DPC micelles

Released:
DOI: 10.2210/pdb6z0i/pdb
PDB entry 6z0i coloured by chain, ensemble of 20 models, front view.
PDB entry 6z0i coloured by chain, ensemble of 20 models, side view.
PDB entry 6z0i coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
γ-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics.
Steiner A, Schlepckow K, Brunner B, Steiner H, Haass C, Hagn F
EMBO J 39 e104247 (2020)
PMID: 32830336

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192733 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Triggering receptor expressed on myeloid cells 2 Chain: A
Molecule details ›
Chain: A
Length: 49 amino acids
Theoretical weight: 5.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZC2 (Residues: 161-206; Coverage: 22%)
Gene name: TREM2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 28%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Interpretable artificial intelligence and exascale molecular dynamics simulations to reveal kinetics: Applications to Alzheimer's disease.
Martin et al. (2022)
1 more

1 mention without citation

Structural biology of cell surface receptors implicated in Alzheimer's disease.
Hermans et al. (2022)