› 6yll

X-ray diffraction
2.89Å resolution

Biochemical, Cellular and Structural Characterization of Novel ERK3 Inhibitors

Released:
DOI: 10.2210/pdb6yll/pdb
PDB entry 6yll coloured by chain, front view.
PDB entry 6yll coloured by chain, side view.
PDB entry 6yll coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors.
Grädler U, Busch M, Leuthner B, Raba M, Burgdorf L, Lehmann M, Linde N, Esdar C
Bioorg Med Chem Lett 30 127551 (2020)
PMID: 32927028

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172545 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 319 amino acids
Theoretical weight: 36.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16659 (Residues: 9-327; Coverage: 44%)
Gene names: ERK3, MAPK6, PRKM6
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:
Ligand OYB 1 x OYB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P43212
Unit cell:
a: 85.12Å b: 85.12Å c: 181.26Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.246 0.245 0.263
Expression system: Escherichia coli

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