6yll

X-ray diffraction
2.89Å resolution

Biochemical, Cellular and Structural Characterization of Novel ERK3 Inhibitors

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 319 amino acids
Theoretical weight: 36.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16659 (Residues: 9-327; Coverage: 44%)
Gene names: ERK3, MAPK6, PRKM6
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P43212
Unit cell:
a: 85.12Å b: 85.12Å c: 181.26Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.246 0.245 0.263
Expression system: Escherichia coli