› 6yj2

X-ray diffraction
2Å resolution

Structural and DNA binding studies of the transcriptional repressor Rv2506 (BkaR) from Mycobacterium tuberculosis supports a role in L-Leucine catabolism

Released:
DOI: 10.2210/pdb6yj2/pdb
PDB 6yj2 coloured by chain and viewed from the front.
PDB 6yj2 coloured by chain and viewed from the side.
PDB 6yj2 coloured by chain and viewed from the top.
Source organism: Mycobacterium tuberculosis H37Rv
Entry authors: Keep NH, Pritchard JE, Sula A, Cole AR, Kendall SL

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH tetR-type domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 215 amino acids
Theoretical weight: 23.25 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O06169 (Residues: 1-215; Coverage: 100%)
Gene name: Rv2506
Sequence domains: Tetracyclin repressor-like, C-terminal domain

Ligands and Environments

1 bound ligand:
Ligand GOL 8 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: C2
Unit cell:
a: 181.764Å b: 52.874Å c: 91.919Å
α: 90° β: 90.1° γ: 90°
R-values:
R R work R free
0.194 0.192 0.224
Expression system: Escherichia coli BL21(DE3)

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