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Crystal structure of the CREBBP bromodomain in complex with a tetrahydroquinoxaline ligand

Source organism: Homo sapiens
Biochemical function: histone acetyltransferase activity
Biological process: regulation of DNA-templated transcription
Cellular component: not assigned

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EC 2.3.1.48: Histone acetyltransferase

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Systematic name:
Acetyl-CoA:[protein]-L-lysine acetyltransferase
Alternative Name(s):
  • Acetyl-CoA:histone acetyltransferase
  • Histone acetokinase
  • Histone acetylase
  • Histone transacetylase
  • Lysine acetyltransferase
  • Nucleosome-histone acetyltransferase
  • Protein lysine acetyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00439
Domain description: Bromodomain
Occurring in:
  1. CREB-binding protein
The deposited structure of PDB entry 6yik contains 3 copies of Pfam domain PF00439 (Bromodomain) in CREB-binding protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001487
Domain description: Bromodomain
Occurring in:
  1. CREB-binding protein
IPR036427
Domain description: Bromodomain-like superfamily
Occurring in:
  1. CREB-binding protein
IPR018359
Domain description: Bromodomain, conserved site
Occurring in:
  1. CREB-binding protein

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