6y9s

X-ray diffraction
2.03Å resolution

Crystal structure of GSK-3b in complex with the imidazo[1,5-a]pyridine-3-carboxamide inhibitor 16

Released:

Function and Biology Details

Reaction catalysed:
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen synthase kinase-3 beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 350 amino acids
Theoretical weight: 39.88 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P49841 (Residues: 35-384; Coverage: 83%)
Gene name: GSK3B
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 67.109Å b: 96.185Å c: 67.56Å
α: 90° β: 103.59° γ: 90°
R-values:
R R work R free
0.204 0.202 0.249
Expression system: Spodoptera frugiperda