› 6y7l

X-ray diffraction
1.8Å resolution

Structure of the BRD9 bromodomain and TP-472

Released:
DOI: 10.2210/pdb6y7l/pdb
PDB entry 6y7l coloured by chain, front view.
PDB entry 6y7l coloured by chain, side view.
PDB entry 6y7l coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Diaz-Saez L, Krojer T, Picaud S, von Delft F, Filippakopoulos P, Arrowsmith CH, Edwards A, Bountra C, Huber KVM

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190676 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 9 Chain: A
Molecule details ›
Chain: A
Length: 121 amino acids
Theoretical weight: 14.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H8M2 (Residues: 134-243; Coverage: 18%)
Gene names: BRD9, UNQ3040/PRO9856
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:
Ligand QMG 1 x QMG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 107.075Å b: 41.435Å c: 29.681Å
α: 90° β: 101.72° γ: 90°
R-values:
R R work R free
0.164 0.163 0.19
Expression system: Escherichia coli BL21(DE3)

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