› 6y7f

X-ray diffraction
2.05Å resolution

Crystal structure of human ELOVL fatty acid elongase 7 (ELOVL7)

Released:
DOI: 10.2210/pdb6y7f/pdb
PDB entry 6y7f coloured by chain, front view.
PDB entry 6y7f coloured by chain, side view.
PDB entry 6y7f coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Nie L, Pike ACW, Bushell SR, Chu A, Cole V, Speedman D, Rodstrom KEJ, Kupinska K, Shrestha L, Mukhopadhyay SMM, Burgess-Brown NA, Love J, Edwards AM, Arrowsmith CH, Bountra C, Carpenter EP, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106663 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Very long chain fatty acid elongase 7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 288 amino acids
Theoretical weight: 34.26 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: A1L3X0 (Residues: 1-281; Coverage: 100%)
Gene name: ELOVL7
Sequence domains: GNS1/SUR4 family

Ligands and Environments

3 bound ligands:
Ligand OFN 2 x OFN
Ligand 37X 4 x 37X
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P21
Unit cell:
a: 63.229Å b: 72.459Å c: 112.043Å
α: 90° β: 100.03° γ: 90°
R-values:
R R work R free
0.211 0.21 0.226
Expression system: Spodoptera frugiperda

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