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Crystal Structure of Human Deoxyhypusine Synthase in complex with spermidine and NAD

Source organism: Homo sapiens
Biochemical function: identical protein binding
Biological process: spermidine catabolic process
Cellular component: cytosol

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EC 2.5.1.46: Deoxyhypusine synthase

Reaction catalysed:
(1a) spermidine + NAD(+) = dehydrospermidine + NADH
Systematic name:
[eIF5A-precursor]-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming)
Alternative Name(s):
  • (4-aminobutyl)lysine synthase
  • Spermidine dehydrogenase
  • Spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming)
  • [eIF-5A]-deoxyhypusine synthase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01916
Domain description: Deoxyhypusine synthase
Occurring in:
  1. Deoxyhypusine synthase
The deposited structure of PDB entry 6xxj contains 2 copies of Pfam domain PF01916 (Deoxyhypusine synthase) in Deoxyhypusine synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002773
Domain description: Deoxyhypusine synthase
Occurring in:
  1. Deoxyhypusine synthase
IPR036982
Domain description: Deoxyhypusine synthase superfamily
Occurring in:
  1. Deoxyhypusine synthase
IPR029035
Domain description: DHS-like NAD/FAD-binding domain superfamily
Occurring in:
  1. Deoxyhypusine synthase

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