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X-ray diffraction
1.41Å resolution

Crystal Structure of Human Deoxyhypusine Synthase in complex with spermidine and NAD

Released:

Function and Biology Details

Reaction catalysed:
(1a) spermidine + NAD(+) = dehydrospermidine + NADH
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Deoxyhypusine synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 369 amino acids
Theoretical weight: 41.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49366 (Residues: 1-369; Coverage: 100%)
Gene names: DHPS, DS
Sequence domains: Deoxyhypusine synthase

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P3221
Unit cell:
a: 105.486Å b: 105.486Å c: 160.831Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.143 0.142 0.16
Expression system: Escherichia coli BL21(DE3)