PDB 6xvk biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

Download 3D Visualisation

Assembly Name: Vascular endothelial growth factor receptor 2
hide full assembly name

Multimeric state: monomeric

PDBe Complex ID: PDB-CPX-153084

$Monomeric assembly 1 of PDB entry 6xvk coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Vascular endothelial growth factor receptor 2;</li> <li class='image_legend_li'>1 copy of ~{N}-(4,4-dimethyl-2-prop-1-ynyl-3,1-benzoxazin-6-yl)-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 6xvk coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Vascular endothelial growth factor receptor 2;</li> <li class='image_legend_li'>1 copy of ~{N}-(4,4-dimethyl-2-prop-1-ynyl-3,1-benzoxazin-6-yl)-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 6xvk coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Vascular endothelial growth factor receptor 2;</li> <li class='image_legend_li'>1 copy of ~{N}-(4,4-dimethyl-2-prop-1-ynyl-3,1-benzoxazin-6-yl)-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Macromolecules

Vascular endothelial growth factor receptor 2

Chain: A
Length: 322 amino acids
Theoretical weight: 36.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:

Canonical: P35968 (Residues: 806-1171; Coverage: 24%)

Gene names: FLK1, KDR, VEGFR2
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:

Protein kinase-like domain superfamily
Protein kinase domain
Serine-threonine/tyrosine-protein kinase, catalytic domain
Tyrosine-protein kinase, catalytic domain
Protein kinase, ATP binding site
Tyrosine-protein kinase, receptor class III, conserved site
Tyrosine-protein kinase, active site

Vascular endothelial growth factor receptor 2 in PDB entry 6xvk, assembly 1, front view.

Vascular endothelial growth factor receptor 2 in PDB entry 6xvk, assembly 1, side view.

Vascular endothelial growth factor receptor 2 in PDB entry 6xvk, assembly 1, top view.

FASTA Sequence


    >pdb|6xvk|A

MDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKVAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDENLYFQ

PDBe-KB: UniProt Coverage View: P35968

Molecule details ›

Download

FASTA (Protein chains A)
Archive mmCIF file
Updated mmCIF file
PDB file
PDB header
PDB file (gz)
PDBML
PDBML (ATOM lines)
PDBML (no atoms)
Structure Factors
SIFTS XML file with residue-level mappings

Search similar proteins

Similar 3D structures (PDBeFold)
Similar sequences

BLAST P35968 (UniProt)

Protein Data Bank in Europe

Crystal structure of the KDR (VEGFR2) kinase domain in complex with a type-II inhibitor bearing an acrylamide

Quick links

Assemblies

Assembly 1 (preferred)

Macromolecules

Search similar proteins

Quick links

PDBe › 6xvk › Structure analysis

Crystal structure of the KDR (VEGFR2) kinase domain in complex with a type-II inhibitor bearing an acrylamide

Quick links

Assemblies

Assembly 1 (preferred)

Macromolecules

Search similar proteins

Quick links

6xvk › Structure analysis