6xvc

X-ray diffraction
1.1Å resolution

CRYSTAL STRUCTURE OF BRD4-BD1 WITH COMPOUND 1

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: B
Molecule details ›
Chain: B
Length: 127 amino acids
Theoretical weight: 15.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 39.197Å b: 50.466Å c: 57.537Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.172 0.198
Expression system: Escherichia coli