X-ray diffraction
2.15Å resolution

Crystal structure of the kinase domain of human c-KIT with a cyclic imidate inhibitor covalently bound to Cys788


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Mast/stem cell growth factor receptor Kit Chains: A, B
Molecule details ›
Chains: A, B
Length: 328 amino acids
Theoretical weight: 37.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P10721 (Residues: 551-687, 766-934; Coverage: 32%)
  • Best match: P10721-4 (Residues: 47-215)
Gene names: KIT, SCFR
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 87.71Å b: 90.272Å c: 91.178Å
α: 90° β: 90° γ: 90°
R R work R free
0.194 0.192 0.223
Expression system: Escherichia coli BL21(DE3)