› 6xsw

X-ray diffraction
2.98Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-233697 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Anti-N3 Fab Heavy Chain Chains: A, D, G, H
Molecule details ›
Chains: A, D, G, H
Length: 231 amino acids
Theoretical weight: 24.71 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
Anti-N3 Fab Light Chain Chains: B, E, I, L
Molecule details ›
Chains: B, E, I, L
Length: 214 amino acids
Theoretical weight: 23.51 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
Notch 3 extracellular truncation Chains: C, F, J, X
Molecule details ›
Chains: C, F, J, X
Length: 280 amino acids
Theoretical weight: 31.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UM47 (Residues: 1378-1634; Coverage: 11%)
Gene name: NOTCH3
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand CA 13 x CA
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 133.652Å b: 158.951Å c: 159.687Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.233 0.256
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Caveolar and non-Caveolar Caveolin-1 in ocular homeostasis and disease.
Enyong et al. (2022)
2 more

1 mention without citation

NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells.
Geles et al. (2021)