› 6xr5

X-ray diffraction
1.7Å resolution

Crystal Structure of Diphosphomevalonate decarboxylase (MVD1) Cryptococcus neoformans var. grubii serotype A

Released:
DOI: 10.2210/pdb6xr5/pdb
PDB entry 6xr5 coloured by chain, front view.
PDB entry 6xr5 coloured by chain, side view.
PDB entry 6xr5 coloured by chain, top view.
Source organism: Cryptococcus neoformans var. grubii H99
Entry author: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Function and Biology Details

Reaction catalysed: 
ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125430 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Diphosphomevalonate decarboxylase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 403 amino acids
Theoretical weight: 43.91 KDa
Source organism: Cryptococcus neoformans var. grubii H99
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: J9VRT5 (Residues: 1-395; Coverage: 100%)
Gene name: CNAG_05125
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand SO4 12 x SO4
Ligand ADE 5 x ADE
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21
Unit cell:
a: 95.51Å b: 168.05Å c: 101.21Å
α: 90° β: 90.14° γ: 90°
R-values:
R R work R free
0.156 0.156 0.182
Expression system: Escherichia coli BL21(DE3)

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