6xr4

Electron Microscopy
14Å resolution

Integrative in situ structure of Parkinsons disease-linked human LRRK2

Released:
Source organism: Homo sapiens
Related structures: EMD-20825

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leucine-rich repeat serine/threonine-protein kinase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 2527 amino acids
Theoretical weight: 286.45 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q5S007 (Residues: 1-2527; Coverage: 100%)
Gene names: LRRK2, PARK8
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 14Å
Relevant EMDB volumes: EMD-20825