› 6xjb

Electron Microscopy
3.8Å resolution

IgA1 Protease

Released:
DOI: 10.2210/pdb6xjb/pdb
PDB entry 6xjb coloured by chain, front view.
PDB entry 6xjb coloured by chain, side view.
PDB entry 6xjb coloured by chain, top view.
Source organism: Streptococcus pneumoniae R6
Primary publication:
Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease.
Wang Z, Rahkola J, Redzic JS, Chi YC, Tran N, Holyoak T, Zheng H, Janoff E, Eisenmesser E
Nat Commun 11 6063 (2020)
PMID: 33247098
Related structures: EMD-22205

Function and Biology Details

Reaction catalysed: 
Cleavage of Pro-|-Thr bond in the hinge region of the heavy chain of human IgA.
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176830 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunoglobulin A1 protease Chain: A
Molecule details ›
Chain: A
Length: 1285 amino acids
Theoretical weight: 144.43 KDa
Source organism: Streptococcus pneumoniae R6
Expression system: Escherichia coli
UniProt:
  • Canonical: Q59947 (Residues: 674-1958; Coverage: 67%)
Gene names: iga, spr1042
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-22205
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Pathogenesis of IgA Nephropathy: Current Understanding and Implications for Development of Disease-Specific Treatment.
Knoppova et al. (2021)
6 other articles

1 mention without citation

Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease.
Wang et al. (2020)