› 6xfp

X-ray diffraction
2Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147199 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase B-raf Chain: A
Molecule details ›
Chain: A
Length: 288 amino acids
Theoretical weight: 32.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15056 (Residues: 442-721; Coverage: 37%)
Gene names: BRAF, BRAF1, RAFB1
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

2 bound ligands:
Ligand V1Y 1 x V1Y
Ligand CL 6 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: C2221
Unit cell:
a: 48.793Å b: 119.563Å c: 103.934Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.204 0.257
Expression system: Escherichia coli

Quick links

Citations

18 review citations

Signal pathways of melanoma and targeted therapy.
Guo et al. (2021)
17 more

5 mentions without citation

Transformer-Based Generative Model Accelerating the Development of Novel BRAF Inhibitors.
Yang et al. (2021)
4 more