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Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution- and Solid-State Investigations.

Miron CE, van Staalduinen L, Rangaswamy AM, Chen M, Liang Y, Jia Z, Mergny JL, Petitjean A
Angew Chem Int Ed Engl 60 2500-2507 (2021)
Cited: 6 times
EuropePMC logo PMID: 33090592

Abstract

Guanine quadruplex recognition has gained increasing attention, inspired by the growing awareness of the key roles played by these non-canonical nucleic acid architectures in cellular regulatory processes. We report here the solution and solid-state studies of a novel planar platinum(II) complex that is easily assembled from a simple ligand, and exhibits notable binding affinity for guanine quadruplex structures, while maintaining good selectivity for guanine quadruplex over duplex structures. A crystal structure of this ligand complexed with a telomeric quadruplex confirms double end-capping, with dimerization at the 5' interface.

Reviews - 6xcl mentioned but not cited (1)

  1. Insights into the Small Molecule Targeting of Biologically Relevant G-Quadruplexes: An Overview of NMR and Crystal Structures. Criscuolo A, Napolitano E, Riccardi C, Musumeci D, Platella C, Montesarchio D. Pharmaceutics 14 2361 (2022)


Reviews citing this publication (1)

  1. Designing Artificial Metalloenzymes by Tuning of the Environment beyond the Primary Coordination Sphere. Van Stappen C, Deng Y, Liu Y, Heidari H, Wang JX, Zhou Y, Ledray AP, Lu Y. Chem Rev 122 11974-12045 (2022)

Articles citing this publication (4)

  1. Ruthenium Polypyridyl Complex Bound to a Unimolecular Chair-Form G-Quadruplex. McQuaid KT, Takahashi S, Baumgaertner L, Cardin DJ, Paterson NG, Hall JP, Sugimoto N, Cardin CJ. J Am Chem Soc 144 5956-5964 (2022)
  2. G-quadruplex structural transition driven by a platinum compound. Liu W, Zhu BC, Liu LY, Xia XY, Mao ZW. Nucleic Acids Res 50 7816-7828 (2022)
  3. G-quadruplex targeting chemical nucleases as a nonperturbative tool for analysis of cellular G-quadruplex DNA. Yu Z, Hendricks AL, Cowan JA. iScience 24 102661 (2021)
  4. Parallel G-Quadruplex DNA Structures from Nuclear and Mitochondrial Genomes Trigger Emission Enhancement in a Nonfluorescent Nano-aggregated Fluorine-Boron-Based Dye. Deiana M, Chand K, Chorell E, Sabouri N. J Phys Chem Lett 14 1862-1869 (2023)


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