› 6xcj

X-ray diffraction
2.8Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Envelope glycoprotein gp160 Chain: G
Molecule details ›
Chain: G
Length: 357 amino acids
Theoretical weight: 39.71 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A0A7I3C6 (Residues: 40-475; Coverage: 42%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
DH650 Fab Heavy Chain Chain: H
Molecule details ›
Chain: H
Length: 226 amino acids
Theoretical weight: 24.29 KDa
Source organism: Macaca mulatta
Expression system: Homo sapiens
DH650 Fab Light Chain Chain: L
Molecule details ›
Chain: L
Length: 220 amino acids
Theoretical weight: 24.14 KDa
Source organism: Macaca mulatta
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand NAG 9 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21212
Unit cell:
a: 138.52Å b: 122.1Å c: 53.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.227 0.284
Expression system: Homo sapiens

Quick links

Citations

6 review citations

Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.
Haynes et al. (2022)
5 more

1 mention without citation

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.
Roark et al. (2021)